Figure 11.
Long-term effects of intrahippocampal α-syn fibril injection on regional tissue levels of Ser129-phosphorylated α-syn (P-α-syn), non-phosphorylated α-syn (non-P-α-syn), and PrPc. Representative Western blotting bands and densitometric analyses illustrate the expression levels of the various proteins in the hippocampus (A, A’, D, D’), fronto-parietal cortex (B, B’, E, E’), and prefrontal cortex (C, C’, F, F’) of rats injected with α-syn fibrils and controls at 12 months postinjection. The values are shown as a percentage of P-α-syn, non-P-α-syn forms, or PrPc relative to β-actin, this latter being the loading control. Data are represented as mean ± SEM. Asterisk in A’ indicates significant difference from control at p < 0.05.