Fig. 1.

Direct sequencing of PCR antisense products in thyroid tumor samples obtained from 14 patients revealing the presence of (a corresponding with patient no. 2) the BRAF p.V600E variant in six patients, (b corresponding with patient no. 1) the NRAS p.Q61R variant in two patients, and (c corresponding with patient no. 17) the AIP p.Q285 variant in one patient. LOH of chromosome 11 was identified in two of the 15 pituitary tumor samples; one was a partial chromosome 11 LOH deletion. In thyroid tumor samples, in 2 of the 14 samples chromosome 11 was identified; one was a partial chromosome 11 LOH deletion. Chromosome 22 was identified in two of the 14 thyroid tumor samples. (d arrow: corresponding with patient no. 12) Demonstrates a representative example of LOH. LOH loss of heterozygosity