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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 May 21:ciaa623. doi: 10.1093/cid/ciaa623

Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID-19 patients

Jianghong Fan 1, Xinyuan Zhang 1, Jiang Liu 1, Yuching Yang 1, Nan Zheng 1, Qi Liu 2, Kimberly Bergman 2, Kellie Reynolds 3, Shiew-Mei Huang 2, Hao Zhu 1, Yaning Wang 1,
PMCID: PMC7314136  PMID: 32435791

Abstract

Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro EC50/EC90 values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.

Keywords: Hydroxychloroquine, SARS-CoV-2, COVID-19, antiviral activity


Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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