Table 3. Association of burden of ultra-rare ($MAF<0.0001$) PTVs with healthspan and mother’s age at death is sex-specific.

Number of ultra-rare variants was calculated for each genome and tested for association with lifespan phenotypes using Cox proportional hazards model and covariates to account for population structure (see Materials and methods). Beta coefficients reported in the ’coef’ column. Bold font designates statistically significant associations. N - number of individuals analyzed, events - number of corresponding events reported in UK Biobank.

Phenotype	Sex	Coef	Ci (2.5%)	Ci (97.5%)	p-value	N	Events
Death	female	0.048	0.012	0.083	0.008	21742	450
Death	male	0.041	0.011	0.070	0.007	18626	672
Mother age at death	female	0.008	0.001	0.015	0.026	21320	12370
Mother age at death	male	0.006	−0.002	0.013	0.130	17989	11081
Father age at death	female	0.002	−0.004	0.008	0.558	20914	15679
Father age at death	male	−0.001	−0.008	0.006	0.796	17783	13785
Healthspan	female	0.024	0.014	0.034	4.1E-06	21742	5667
Healthspan	male	0.009	−0.001	0.019	0.070	18626	6037