To compare the incomparable: COVID-19 pneumonia and high-altitude disease

The coronavirus disease 2019 (COVID-19) pandemic is overwhelming healthcare systems worldwide. There is no evidence from randomised clinical trials that any potential therapy improves outcome in COVID-19 pneumonia, and therapeutic strategies have been based on a progressively increasing knowledge of the clinical presentation of the disease. Some clinicians have found the clinical features of COVID-19 pneumonia to be similar to high-altitude pulmonary oedema (HAPE) [1], and such theory has been amplified via social media. We question this relationship.

Short abstract

COVID-19 pneumonia is a viral infection; high-altitude pulmonary oedema is a non-cardiogenic oedema. Some clinicians have found the clinical features similar. It is important to clarify such misconceptions to prevent erroneous treatment strategies https://bit.ly/2KOBi3F

To the Editor:

The coronavirus disease 2019 (COVID-19) pandemic is overwhelming healthcare systems worldwide. There is no evidence from randomised clinical trials that any potential therapy improves outcome in COVID-19 pneumonia, and therapeutic strategies have been based on a progressively increasing knowledge of the clinical presentation of the disease. Some clinicians have found the clinical features of COVID-19 pneumonia to be similar to high-altitude pulmonary oedema (HAPE) [1], and such theory has been amplified via social media. We question this relationship.

COVID-19 pneumonia shows diffuse alveolar damage and airway inflammation, reflecting a true virus-related pathology [2], as shown by the first report of pathological findings from autopsies in COVID-19 decedents published at the beginning of April 2020 [1]. Since the end of February 2020, as clinicians from northern Italy and other European countries, we have faced the management of several hundreds of critically ill patients, similarly to other colleagues [3, 4]. Most of the patients with COVID-19 pneumonia who require hospitalisation and intensive care meet the acute respiratory distress syndrome (ARDS) criteria specified in the Berlin definition, but with an unusual clinical manifestation. Hypoxaemia is the main characteristic of all patients with COVID-19 pneumonia and ARDS, but some patients run an unusual course of the disease and show specific abnormalities on chest imaging. These patients show a dissociation between relatively well-preserved lung mechanics and the severity of hypoxaemia. In contrast to classic ARDS, lung volume and dead space in COVID-19 patients are often normal, consolidations absent and pulmonary and chest wall elastance preserved, but a severe capillary leak dominates the initial phase. Whether this severe leak is secondary to virus-triggered inflammation, endothelial cell injury, or direct virus-induced cell destruction, is the subject of ongoing trials. Gattinoni et al. [5] have hypothesised two different phenotypes of COVID-19 pneumonia: a phenotype L, characterised by low elastance, low recruitability, low response to positive end-expiratory pressure (PEEP) and low ventilation/perfusion matching; and a phenotype H (similar to classic ARDS) with high elastance, higher shunt, high recruitability and higher PEEP response. Despite the assumption that patients may progress from phenotype L to phenotype H over time, and that this evolution could be disease- and/or therapy-driven, further evidence is needed to prove this hypothesis.

The assumption that the clinical features of COVID-19 pneumonia are similar to HAPE [1] may rely on the initial clinical presentation of COVID-19 patients, showing profound hypoxaemia with no respiratory distress, similar to patients with acute high-altitude disease that have a chemoreceptor dysfunction. HAPE is a non-cardiogenic pulmonary oedema caused by exaggerated hypoxic pulmonary vasoconstriction and abnormally high pulmonary artery pressure and capillary pressure [6]. These high pressures lead to a non-inflammatory and haemorrhagic alveolar capillary leak in the earlier stages of the disease [7]. Over time, haemorrhagic alveolar capillary leak may also evoke a secondary inflammatory response in HAPE patients [7]. The pathogenesis of the two diseases (HAPE and COVID-19 pneumonia) is clearly different, despite similarities in clinical features, chest imaging and bronchoalveolar lavage findings in later stages, as has recently been emphasised by Luks et al. [8]. Due to the different pathogenesis, adoption of prevention and treatment strategies from HAPE for the treatment of patients with COVID-19 pneumonia could lead to potential pitfalls. Patients with COVID-19 pneumonia often require intensive care, whereas HAPE is a life-threatening condition that almost never needs intensive care, as it can be reversed by oxygen administration, exposure to a relatively hyperbaric environment or transfer to lower altitude [9]. The use of supplemental oxygen in COVID-19 pneumonia does not counteract the underlying pathogenic mechanisms in the way it does in HAPE [9], but only increases oxygen availability. Systemic pulmonary vasodilators such as nifedipine and phosphodiesterase-5 inhibitors could critically worsen ventilation/perfusion mismatch or cause hypotension in COVID-19 patients, where there is no hypoxic pulmonary vasoconstriction like in HAPE [6] but rather a dysregulation of lung perfusion and impaired hypoxic vasoconstriction. Despite its established role in prevention and treatment of HAPE [9], corticosteroid use in COVID-19 pneumonia is still under debate in the scientific community [10] and currently not advised by the World Health Organization.

We consider it important to clarify such misconceptions, in order to prevent the spreading of erroneous treatment strategies when caring for COVID-19 patients. COVID-19 disease has been reported to affect high-altitude areas [11] and, interestingly, the spread of the disease in certain areas of northern Italy has started from villages in mountainous areas that are popular with tourists. This does not implicate any coincidence between the diseases. Clinicians should focus on the development of therapeutic strategies based on the pathogenesis of the disease, and should remember that COVID-19 pneumonia is a viral infection primarily leading to diffuse alveolar damage and airway inflammation.

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