Dear Editor,
At the end of December-2019 in china Wuhan city a viral infection transmission started from person to person effecting human body with many infections named as corona-virus [1]. This viral infection spread very rapidly across the china and multiplied in number in a very short time and migrated to other country by person migration. The WHO (World Health Organization) director general declared on January 30, 2020 that corona virus outbreak, health safety and emergency are recommended under the international health regulations [2]. On February 2, 2020 the China NHC (National Health Commission) reported about 304 deaths in a total of 14,488 cases in china and from other country total 146 cases confirmed with death number 1. This viral diseases is still continues throughout the world and today so many country are effected from that so proper attention towards this are needed and is important to discover and design therapeutic agents for this infection either form natural or from synthetic source. High risk and isolation should be preferred social interaction hand shaking must be stop and proper attention should be given at first positive stage. There are still no such effective antiviral drug or any vaccines are available for the corona virus infection because any specific treatment and drug designing required a lot of time however traditional Chinese medication is might available in 2003 outbreak of contagious disease severe acute respiratory syndrome (SARS) [3].
In china government recommended the usage of herbal medicine against viral-pneumonia and depend on sign and symptoms of patients and full literature of herbs were noticed before employment and is not necessary that it might possess direct antiviral pathology and potential but if possess it would be might useful for doctor in selection during the outbreak of severe acute respiratory syndrome (SARS) researcher given to Chinese traditional herbal medicinal plants and finding a novel and targeted and anti-corona viral compounds [4]. Found that this virus possess a number of protein helpful in replication most of them are Spike, 3CLprot (3C Like Protease) and PLprot (Papain Like Protease) protein were mainly studied the PLprot help in virus polypeptide protein and enzyme deubiquitinating for host against virus and eliminating the Ub (Ubiquitin) system. According to Ref. [5] In severe acute respiratory syndrome the PLprot breaks the UB-Like Protein ISG15, while LYS58 can linked the Poly-Ub Chain and releases in product DiUbLys48 while [6] reported that 3CLprot is responsible as cysteine-protease in the life cycle of virus and the spike protein Of Corona viruses uses angiotensin converting enzyme-II for receptor and provides help in of virus to inside the cell. These types of protein are helpful towards the new targeted designing of drug discovery. The naturally isolated compounds small molecules were screen and direct inhibition potency of proteins in severe acute respiratory syndrome was noticed in corona-virus. According to recent study that corona virus of 2019 gene in sequences were very closed in protein with SARS and MERS a severe acute respiratory syndrome and Middle East respiratory syndrome corona-virus. So it might easy to utilized the Traditional Chinese Herbal Medication for viral-pneumonia treatment and help in 2019 anti-corona virus in the light of MERS corona and SARS corona and is important to screen out the compounds for patients effected with this pathogen and need to find out any alternate of corona virus 2019 in a very short time.
Now it's necessary to find out anti-corona virus via herbal medication for those patients who suffer from that. In traditional Chinese medicine thirteen compounds found potent against anti-corona viral activity about one twenty-five herbs possess 2–13 compounds and twenty-six recommended shown in [Table 1 ] based on pharmacology for treating viral-respiratory infection and immune inflammation and posses direct effect against corona virus (COVID-19). The traditional or conventional medicine called drugs from plant preferred and recommended by a number of people due to zero or less health related side effects and is very effective efficient these herbs possess antiviral potential such as treating CORONA-VIRUS 2019 (COVID-19) pneumonia a respiratory viral infection; consideration and further evaluation are very important.
Table 1.
The list of 26 Traditional Chinese Herbs containing antiviral compound and their usage.
| Serial Number | Herbal Plant Name | No. of Antiviral Compound Contain | Catalogue | Course Timing |
|---|---|---|---|---|
| 1 | Lonicerae japonicae flos | 2 | Antipyretic detoxifying | Full |
| 2 | Hoveniae dulcis semen | 2 | Antipyretic detoxifying | Middle |
| 3 | Forsythiae fructus | 3 | Antipyretic detoxifying | Full |
| 4 | Rhizoma fagopyri cymosi | 2 | Antipyretic detoxifying | Early |
| 5 | Houttuyniae herba | 2 | Antipyretic detoxifying | Middle |
| 6 | Farfarae flos | 2 | Antitussive antiasthmatics | Full |
| 7 | Eriobotryae folium | 3 | Antitussive antiasthmatics | Middle-Later |
| 8 | Mori cortex | 3 | Antitussive antiasthmatics | Full |
| 9 | Ardisiae japonicae herba | 2 | Antitussive antiasthmatics | Middle-Later |
| 10 | Ardisiae japonicae herba | 2 | Antitussive antiasthmatics | Middle-Later |
| 11 | Lepidii semen descurainiae semen | 3 | Antitussive antiasthmatics | Middle-Later |
| 12 | Ginkgo semen | 2 | Antitussive antiasthmatics | Later |
| 13 | Radix bupleuri | 2 | Pungent cool diaphoretics | Middle |
| 14 | Chrysanthemi flos | 2 | Pungent cool diaphoretics | Full |
| 15 | Mori follum | 2 | Pungent cool diaphoretics | Full |
| 16 | Tamaricis cacumen | 3 | Pungentwarm exterior | Early |
| 17 | Erigeron breviscapus | 2 | Pungentwarm exterior | Early |
| 18 | Coptidis rhizome | 2 | Heat-clearing and dampness | Middle |
| 19 | Inulae flos | 2 | Phlegm resolving medicine | Middle-Later |
| 20 | Peucedani radix | 2 | Phlegm-resolving medicine | Full |
| 21 | Licorice | 3 | Qi-reinforcing | Full |
| 22 | Hedysarum multijugum maxim | 3 | Qi-reinforcing | Middle-Later |
| 23 | Euphorbiae helioscopiae herba | 2 | Diuretic dampness-excreting | Middle-Later |
| 24 | Anemarrhenae rhizome | 3 | Fire-purging | Later |
| 25 | Epimrdii herba | 2 | Yang-reinforcing | Later |
| 26 | Fortunes bossfern rhizome | 2 | Warming interior | Prevention |
Funding statement
None.
Declaration of competing interest
The author has no conflict of interest.
Acknowledgment
Special thanks to Professor Himayat Ullah of Chemistry Department Government Post Graduate College Mardan 23200 KP Pakistan for mindmaps during the study.
References
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