Table 2.
Physical state, yield, thermal properties (Tg), and reaction time obtained for all compounds in each synthetic method [46].
| Acid-base Neutralization (Traditional Method) | Mechanochemistry (New Method) | |||||||
|---|---|---|---|---|---|---|---|---|
| Compound Name a | Physical State at RT | Yield (%) | Tg (°C) | Reaction Time (h) | Physical State at RT | Yield (%) | Tg (°C) | Reaction Time (min) |
| (EMIM)(GBP) | Transparent liquid | 96.5 | −70.9 | 15 | Transparent liquid | 97.7 | −72.2 | 180b |
| (choline)(GBP) | Transparent viscous liquid | 98.5 | −59.2 | 15 | Transparent viscous liquid | 99.0 | −59.0 | 180b |
| (GBP)(D-glu) | Orange viscous liquid | 92.5 | −48.6 | 10 | Orange viscous liquid | 95.2 | −44.0 | 30 |
| (GBP)(gly) | Transparent liquid | 97.2 | −56.2 | 10 | Transparent liquid | 99.3 | −49.1 | 15 |
| (TMG)(L-glut) | Light yellow liquid | 93.7 | −36.2 | 6 | Light yellow liquid | 97.0 | −38.9 | 10 |
| (DBU)(L-glut) | Yellow liquid | 98.4 | −39.5 | 6 | Yellow liquid | 99.5 | −44.5 | 10 |
a GBP: gabapentine/solid; EMIN—ethyl-methylimidazolium/solid; D-glu: D-gluconic acid/solid; gly: glycolic acid/solid; TMG: tetramethylguanidine/liquid; L-glut: L-glutamic acid/solid; DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene/liquid. bThe time considered is the total time starting from the ionic exchange process and the concentration of the reagent (to eliminate the solvent excess) until the end of the reaction itself (grinding both starting materials). Considering the grinding process, only 30 min were required to finish the reaction.