Table 2.
Production Technique | Species | By-Products | Bioactive Compound | Extraction Method | Bioactivities | Reference |
---|---|---|---|---|---|---|
Submerged Liquid Fermentation | Agaricus bisporus | Mycelia | Gallic, p-coumaric, cinnamic and p-hydroxybenzoic acid | Extraction with methanol:water (80:20, v/v) at −20 °C for 1.5 h. | Antioxidant | [107] |
mycelia and culture media | p-Hydroxybenzoic, p-coumaric and cinnamic acid | Extraction with methanol at 25 °C, 150 rpm for 1 h. | Anti-inflammatory Cytotoxic Antioxidant |
[108] | ||
Inonotus obliquus | Fermentation Broth, Mycelia | Gallic, ferulic, Epigallocatechin gallate, Phelligridin G, Davallialactone and Inoscavin B | Fermentation Broth -Extraction with 95% ethanol (1:4, v/v) at 4 °C overnight, Supernatant re-extracted with ethyl acetate (1:3, v/v) thrice Mycelial-Extraction by ultrasonication for 10 min in 70% aqueous acetone (v/v). |
Antioxidant | [109] | |
I. obliquus | Fermentation Broth, Mycelia | Epicatechin-3-gallate, epigallocatechin-3-gallate, phelligridin G, davallialactone and inoscavin B | Fermentation Broth -Extraction with 95% ethanol (1:4, v/v) at 4 °C overnight, Supernatant re-extracted with ethyl acetate and n-butanol (1:3, v/v) thrice Mycelial-Extraction by ultrasonication for 10 min in 70% aqueous acetone (v/v). |
DPPH radical scavenging | [110] | |
I. obliquus | Mycelia | Kaempferol, quercetin, isorhamnetin, luteolin, naringenin, apigenin, fortuneletin | Mycelial biomass was dried in a microwave oven for 10 min, extracted with 95% ethanol and stored at 4 °C overnight Centrifugation at 4500× g for 10 min. | Superoxide and DPPH radical Scavenging | [111] | |
Lentinula edodes | Mycelia | Protocatechuic and p-hydroxybenzoic acid | Extracted with methanol:water (80:20, v/v) at −20 °C for 1.5 h. |
Antioxidant | [107] | |
Pleurotus eryngii | Mycelia and culture media | p-Hydroxybenzoic and cinnamic acid | Extracted with methanol at 25 °C, 150 rpm for 1 h. | Anti-inflammatory Cytotoxic Antioxidant |
[112] | |
Pleurotus ostreatoroseus | Mycelia | Cinnamic acid | Extracted with ethanol (70%) at 25 °C and at 130 rpm for 3 h. | Antioxidant Anti-inflammatory Antimicrobial Hepatotoxicity |
[113] | |
Suillus belinii | Mycelia and culture media |
p-Hydroxybenzoic acid, Cinnamic acid |
Extracted with methanol at 25 °C, 150 rpm for 1 h. | Anti-inflammatory Cytotoxic Antioxidant activity |
[112] | |
Solid Substrate Fermentation | Cordyceps militaris | Dried powder | Shikmic, chlorogenic, syringic, p-coumaric and ferulic acid, rutin, genistin, daidzein, luteolin, genistein, Biochanin A | Extraction with methanol (80%) and ethanol (80%) at 50 °C for 4 h. Refluxing at 40 °C, at 150 rpm for 4 h. Centrifuged at 15,000× g, for 15 min at 4 °C | Antioxidant activities Inhibition of oxidative DNA damage |
[114] |
Pleurotus eryngii | Substrate | Chlorogenic, syringic, ferulic, p-coumaric, caffeic, t-cinnamic, vanillic acid and naringenin | Extraction in 80% methanol under sonication for 8 h. | Antioxidant activity | [115] | |
Pleurotus ostreatus | Substrate | Chlorogenic, syringic, ferulic, p-coumaric, caffeic, t-cinnamic, vanillic acid and naringenin | Extraction in 80% methanol under sonication for 8 h. | Antioxidant activity | [115] |