Table 4:
Immune Function or Mitochondrial Respiration | IL-8 | IL-10 | TNF-α | INF-γ | MCP-1 |
---|---|---|---|---|---|
Control (n = 18) | |||||
LPS-stim TNF-α | −0.26 | −0.13 | 0.10 | 0.34 | 0.15 |
mHLA-DR | −0.48 | −0.32 | 0.02 | −0.08 | −0.07 |
SRCc | −0.01 | −0.16 | 0.14 | −0.03 | 0.08 |
Sepsis Day 1–2 (T1, n = 137) | |||||
LPS-stim TNF-α | −0.31b | −0.27a | −0.26a | −0.10 | −0.34b |
mHLA-DR | −0.07 | 0.04 | 0.01 | 0.06 | −0.12 |
SRCc | −0.28a | −0.18 | −0.12 | −0.20 | −0.23a |
Sepsis Day 3–5 (T2, n = 104) | |||||
LPS-stim TNF-α | −0.28a | −0.23 | −0.17 | −0.04 | −0.28a |
mHLA-DR | −0.39b | −0.25 | 0.32a | 0.26 | 0.08 |
SRCc | −0.31a | −0.05 | −0.09 | −0.01 | −0.06 |
Sepsis Day 8–14 (T3, n = 70) | |||||
LPS-stim TNF-α | −0.08 | −0.03 | −0.05 | −0.08 | −0.19 |
mHLA-DR | −0.31 | −0.10 | 0.25 | 0.21 | −0.04 |
SRCc | −0.16 | −0.18 | −0.01 | −012 | 0.04 |
LPS-stim TNF-α, ex vivo LPS-stimulated whole blood TNF-α; mHLA-DR, monocyte HLA-DR; SRC, spare respiratory capacity
Statistical significance remained at p<0.01 after correction for multiple comparisons
Statistical significance remained at p<0.001 after correction for multiple comparisons
SRC demonstrated the strongest correlation with plasma cytokines among all mitochondrial respiration parameters and therefore only these data are shown