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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Shock. 2020 Sep;54(3):285–293. doi: 10.1097/SHK.0000000000001486

Table 4:

Correlation of Immune Function and Mitochondrial Respiration with Plasma Cytokines

Immune Function or Mitochondrial Respiration IL-8 IL-10 TNF-α INF-γ MCP-1
Control (n = 18)
 LPS-stim TNF-α −0.26 −0.13 0.10 0.34 0.15
 mHLA-DR −0.48 −0.32 0.02 −0.08 −0.07
 SRCc −0.01 −0.16 0.14 −0.03 0.08
Sepsis Day 1–2 (T1, n = 137)
 LPS-stim TNF-α −0.31b −0.27a −0.26a −0.10 −0.34b
 mHLA-DR −0.07 0.04 0.01 0.06 −0.12
 SRCc −0.28a −0.18 −0.12 −0.20 −0.23a
Sepsis Day 3–5 (T2, n = 104)
 LPS-stim TNF-α −0.28a −0.23 −0.17 −0.04 −0.28a
 mHLA-DR −0.39b −0.25 0.32a 0.26 0.08
 SRCc −0.31a −0.05 −0.09 −0.01 −0.06
Sepsis Day 8–14 (T3, n = 70)
 LPS-stim TNF-α −0.08 −0.03 −0.05 −0.08 −0.19
 mHLA-DR −0.31 −0.10 0.25 0.21 −0.04
 SRCc −0.16 −0.18 −0.01 −012 0.04

LPS-stim TNF-α, ex vivo LPS-stimulated whole blood TNF-α; mHLA-DR, monocyte HLA-DR; SRC, spare respiratory capacity

a

Statistical significance remained at p<0.01 after correction for multiple comparisons

b

Statistical significance remained at p<0.001 after correction for multiple comparisons

c

SRC demonstrated the strongest correlation with plasma cytokines among all mitochondrial respiration parameters and therefore only these data are shown