Table 2.
Cost of FMT according to the route of administration (UK £, 2018).
| Procedure | Resource use | Unit costγ | Total cost | Sources | ||||
|---|---|---|---|---|---|---|---|---|
| FMT- colonoscopy | ||||||||
| FMT material ± | 3 unit (150 ml)§ | £650.00 | £1950.00 | BSG & HIS guidelines [10] | ||||
| FMT administration | ||||||||
| Colonoscopy | 1 unit | £947.00 | £947.00 | NHS reference costs [30] | ||||
| Loperamide 2 mg for FMT retention | 1 tablet | £0.10 | £0.10 | BNF [29] | ||||
| Staff cost (gastroenterologist) | 1/2 h | £108.00 | £54.00 | PSSRU 2018 [32] | ||||
| Recovery time | 2 hrs nurse | £27.53 | £55.07 | Expert opinion | ||||
| Total cost | £3006.17 | |||||||
| FMT nasogastric tube (NGT) | ||||||||
| FMT material± | 1 unit (50 ml)§ | £650.00 | £650.00 | BSG & HIS guidelines [10] | ||||
| FMT administration | ||||||||
| Omeprazole 20 mg / 2 h prior procedure | 1 tablet¥ | £0.03 | £0.03 | BNF [29] | ||||
| Domperidone/ 2 h prior procedure | 1 tablet¥ | £0.03 | £0.03 | BNF [29] | ||||
| NG tube | 1 unit | £7.86* | £7.86 | ASGE [54] | ||||
| Staff cost (HCP) to place the tube | 12 min¥ | £27.53 | £5.51 | PSSRU 2018 [32] | ||||
| X ray | 1 unit | £55.67 | £57.06 | NHS reference cost [30] | ||||
| Recovery time | 1 hrs nurse | £27.53 | £27.53 | Expert opinion | ||||
| Total cost | £740.16 | |||||||
† FMT, Faecal Microbiota Transplant; BNF, British National formulary; PSSRU, Personal Social Service Research Unit; ASGE, American Society for Gastrointestinal Endoscopy; HCP, Health Care Professional.
- Costs of additional tests and follow up were not considered as they are the same for both.
Each unit price (obtained from Queen Elizabeth Hospital - Birmingham) represents the cost of donor selection and testing, preparation and storage prior administration.
Inflated to 2018 costs using the UK Hospital and Community Health Services pay and prices index.
Number of FMT units required for each procedure were based on expert opinion.
Data on resource use were obtained from a published study.
An informal price was provided from expert opinion at University Of Birmingham which was within the same range as the price presented by the ASGE Technology Committee when appropriately converted to UK currency and inflated to 2018 price year.