Table 5.
Summary of sensitivity analysis results relative to FMT- NGT.
| Treatment option | Expected Value | Difference | ICER | ||
|---|---|---|---|---|---|
| Costs £ | QALYs | Cost £ | QALYs | £/ QALYs | |
| Scenario 1: Similar efficacy for FMT colonoscopy and NGT | |||||
| FMT – NGT | 8406 | 0.663 | – | – | – |
| FMT – Colonoscopy | 11,716 | 0.657 | 3311 | −0.007 | Dominated |
| Fidaxomicin | 14,399 | 0.577 | 5993 | −0.086 | Dominated |
| Vancomycin | 17,279 | 0.513 | 8873 | −0.151 | Dominated |
| Scenario 2: Recurrence rate=0.2 for all treatment options | |||||
| FMT – NGT | 10,706 | 0.615 | – | – | – |
| FMT – Colonoscopy | 14,779 | 0.600 | 4073 | −0.015 | Dominated |
| Fidaxomicin | 15,389 | 0.561 | 4683 | −0.053 | Dominated |
| Vancomycin | 16,635 | 0.520 | 5929 | −0.094 | Dominated |
| Scenario 3: constant efficacy for FMT options for the 1st and 2nd dose | |||||
| FMT – NGT | 8281 | 0.671 | – | – | – |
| FMT – Colonoscopy | 11,402 | 0.670 | 3121 | −0.001 | Dominated |
| Fidaxomicin | 14,395 | 0.577 | 6117 | −0.094 | Dominated |
| Vancomycin | 17,279 | 0.513 | 8998 | −0.159 | Dominated |
| Scenario 4: 10 days hospital stay for FMT | |||||
| FMT – NGT | 11,786 | 0.645 | – | – | – |
| Fidaxomicin | 14,399 | 0.577 | 2612 | −0.068 | Dominated |
| FMT – Colonoscopy | 14,585 | 0.657 | 2799 | +0.012 | 239,063 |
| Vancomycin | 17,279 | 0.513 | 5493 | −0.132 | Dominated |
| Scenario 5: 6 weeks hospital stay for vancomycin TP | |||||
| FMT – NGT | 23,498 | 0.645 | – | – | – |
| FMT – Colonoscopy | 25,404 | 0.657 | 1906 | +0.012 | 162,801 |
| Fidaxomicin | 41,325 | 0.577 | 17,827 | −0.068 | Dominated |
| Vancomycin | 46,564 | 0.513 | 23,066 | −0.132 | Dominated |
| Scenario 6: CDI related Mortality for FMT = 12% | |||||
| FMT – NGT | 9034 | 0.653 | – | ||
| FMT – colonoscopy | 11,843 | 0.662 | 2809 | +0.009 | 301,022 |
| Fidaxomicin | 14,399 | 0.577 | 5364 | −0.076 | Dominated |
| Vancomycin | 17,279 | 0.513 | 8245 | −0.140 | Dominated |
Abbreviations: ICER, Incremental cost effectiveness ratio; QALYs, Quality Adjusted Life Years; FMT, Faecal Microbiota Tube; NGT, Nasogastric Tube.