Box plot comparing the expression profiles of ATG (angiotensinogen), AT1A (angiotensin II receptor type 1a), AT1B (angiotensin II receptor type 1b), AT2 (angiotensin II receptor type 2), TGF-b (transforming growth factor-beta), TIMP2 (metalloproteinase inhibitor 2) in hearts of SD – Sprague-Dawley rats, SHHF - Spontaneously Hypertensive Heart Failure (SHHF/MccGmiCrl-Leprcp/Crl), SD-ISO - SD rats treated with ISO at the age of 56 week, drinking either water (control groups) or TMAO solution, (n = 6–7 for each series). × - mean value, * indicates significant difference compared with the control group. *p<0.05 by t-test or Mann-Whitney U test.
Figure 4—source data 1. Real-time RT-PCR analysis, expression profiles in heart.