Fig. 2.

Association map of proteomics and clinical traits. Chord diagram of associations

(FDR P < 0•001) between protein profiles and clinical traits obtained from linear mixed effect models. Line thickness is proportional to -log10(P-value) and coloured by clinical trait. Protein features that represent a family of several proteins are denoted with one gene name followed by “*”. Feature names are coloured red if predicted to be actively secreted into blood, or blue if they appear in blood due to cell leakage [9,40] (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).