Table 4. Multivariate analysis to identify factors predictive of MR4.5.
| Univariate analysis | OR | [95% CI OR] | MR4.5 N (%) | No MR4.5 N (%) | p = |
|---|---|---|---|---|---|
| Male | |||||
| Yes | 0.19 | [0.09–0.41] | 20 (33.3) | 47 (72.3) | < .001 |
| No | 40 (66.7) | 18 (27.7) | |||
| Splenomegaly | |||||
| Yes | 0.29 | [0.11–0.79] | 6 (10) | 18 (27.7) | .02 |
| No | 54 (90) | 47 (72.3) | |||
| WBC count (> 150 × 109/L) | |||||
| Yes | 0.22 | [0.10–0.49] | 13 (21.7) | 36 (55.4) | < .001 |
| No | 47 (78.3) | 29 (44.6) | |||
| PLT count (> 300 G/L) | |||||
| Yes | 5.20 | [2.29–11.75] | 49 (81.7) | 30 (46.2) | < .001 |
| No | 11 (18.3) | 35 (53.8) | |||
| Hemoglobin (> 120 g/L) | |||||
| Yes | 1.50 | [0.73–3.05] | 29 (48.3) | 25 (38.5) | .27 |
| No | 31 (51.7) | 40 (61.5) | |||
| High ELTS score | |||||
| Yes | 0.40 | [0.13–1.21] | 5 (8.3) | 12 (18.5) | .11 |
| No | 55 (91.7) | 53 (81.5) | |||
| High Sokal score | |||||
| Yes | 0.71 | [0.30–2.00] | 12 (20) | 17 (26.1) | .42 |
| No | 48 (80) | 48 (73.9) | |||
| ACA or variant translocation | |||||
| Yes | 0.73 | [0.27–1.95] | 8 (13.3) | 11 (17.5) | .53 |
| No | 52 (86.7) | 52 (82.5) | |||
| Transcript e14a2, alone or co-expressed | |||||
| Yes | 3.21 | [1.51–6.80] | 44 (73.3) | 30 (46.2) | .002 |
| No | 16 (26.7) | 35 (53.8) |
| Multivariate analysis | OR | [95% CI OR] | p = |
|---|---|---|---|
| Male | 0.28 | [0.11–0.71] | .007 |
| Splenomegaly | 0.56 | [0.13–2.46] | .45 |
| WBC count | 0.29 | [0.10–0.84] | .02 |
| Platelets | 3.68 | [1.39–9.76] | .009 |
| ELTS score | 2.42 | [0.43–13.38] | .31 |
| e14a2 | 3.25 | [1.30–8.18] | .01 |
Abbreviations: ACA, additional chromosome abnormalities in Ph+ cells; EUTOS, European Treatment and Outcome Study; ELTS; PLT, platelets; WBC, white blood cells. Variables with p values inferior to 0.20 in univariate analysis were included in the multivariate model.