In the article titled “Effect of Selenium-Enriched Garlic Oil against Cytotoxicity Induced by OX-LDL in Endothelial Cells” [1], the ECV-304 cell line has been found to be cross-contaminated by T-24, which is a bladder carcinoma cell line and not of human umbilical vein endothelial cell (HUVEC) origin [2, 3]. Hence, it is not an appropriate cell line to study endothelial cell biology.
The authors said they asked a local hospital for HUVECs and could not find in their records whether or not the type provided was indeed ECV-304 cells.
References
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- 2. ICLAC Register of Misidentified Cell Lines, http://iclac.org/databases/cross-contaminations/
- 3.Capes-Davis A., Theodosopoulos G., Atkin I., et al. Check your cultures! A list of cross-contaminated or misidentified cell lines. International Journal of Cancer. 2010;127(1):1–8. doi: 10.1002/ijc.25242. [DOI] [PubMed] [Google Scholar]