Plasma TRAIL, IFN-α and mRNA for apoptotic ligands and receptors in blood and tonsils. (A) left: Plasma TRAIL in HIV− donors, (n=45), HIV+ patients (n=45) and HAART patients (n=45). (A) right: IFN-α detected by immunohistochemistry in T cell-rich areas of tonsils from HIV− donors, HIV+ patients and HAART patients. mRNA expression for TRAIL (B), FasL (C), DR5 (D) and Fas (E) in isolated blood CD4+ cells (left) and in whole tonsil tissue (right) from HIV− donors, HIV+ patients and HAART patients. Data of B-E were compared by the Mann-Whitney test; NS = not significant (P>0.05). Horizontal bars: median values; upper and lower limits of boxes are 75th and 25th percentiles; vertical lines indicate 90th and 10th percentiles.