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. 2020 Jun 19;9:e56189. doi: 10.7554/eLife.56189

Figure 6. PDGFRα in developmental APCs is essential for adipose tissue development.

(A) A 2-month-old PpargtTA; TRE-Cre; TRE-H2B-GFP; Pdgfrafl/fl male control and AT-PDGFRα-KO mice were analyzed. (B) Body weight. Data are expressed as mean ± SEM. (C) IGW and PGW tissue. (D) Adipose tissue weight. *p<0.05 AT-PDGFRα compared to AT-Con mice. Data are expressed as mean ± SEM. (E) Other tissue weight. Data are expressed as mean ± SEM. (F) Blood glucose level during glucose tolerance test. *p<0.05 AT-PDGFRα-KO compared to control mice. Data are expressed as mean ± SEM. (G) Hematoxylin and eosin (H&E) staining of IGW. Scale = 100 μm. (H) Oil Red O staining of SVF isolated from IGW of control and AT-PDGFRα-KO mice.

Figure 6.

Figure 6—figure supplement 1. PDGFRα in developmental APCs is essential for adipose tissue development.

Figure 6—figure supplement 1.

(A) IGW tissues of 2-month-old PpargtTA; TRE-Cre; TRE-H2B-GFP; Pdgfrafl/fl male control and AT-PDGFRα-KO mice. (B) Hematoxylin and eosin (H&E) staining of ISCW and liver of control and AT-PDGFRα-KO mice. Scale = 100 μm.