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. 2020 Jun 23;23(7):101307. doi: 10.1016/j.isci.2020.101307

Highly Reactive Cyclic Monoaryl Iodoniums Tuned as Carbene Generators Couple with Nucleophiles under Metal-Free Conditions

Haiwen Wang 1, Liyun Liang 1, Zhirong Guo 1, Hui Peng 1, Shuang Qiao 1, Nemai Saha 2, Daqian Zhu 1, Wenbin Zeng 3, Yunyun Chen 4, Peng Huang 1,∗, Shijun Wen 1,5,∗∗
PMCID: PMC7338778  PMID: 32634743

Summary

Cross-coupling reactions between aryl iodide and nucleophiles have been well developed. Iodoniums equipped with a reactive C-I(III) bond accelerate cross-coupling reactions of aryl iodide. Among them, cyclic diaryliodoniums are more atom economical; however; they are often in the trap of metal reliance and encounter regioselectivity issues. Now, we have developed a series of highly reactive cyclic monoaryl-vinyl iodoniums that can be tuned to construct C-N, C-O, and C-C bonds without metal catalysis. Under promotion of triethylamine, coupling reactions with aniline, phenol, aromatic acid, and indole proceed rapidly and regioselectively at room temperature. The carbene species is conceptualized as a key intermediate in our mechanism model. Furthermore, the coupling products enable diversity-oriented synthesis strategy to further build up a chemical library of diverse heterocyclic fragments that are in demand in the drug discovery field. Our current work provides a deep insight into the synthetic application of these highly reactive cyclic iodoniums.

Subject Areas: Chemistry, Catalysis, Organic Chemistry, Organic Synthesis

Graphical Abstract

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Highlights

  • •

    Highly reactive cyclic monoaryl-vinyl iodoniums were designed and synthesized

  • •

    Coupling reactions with various nucleophiles took place in metal-free condition

  • •

    A mechanism involving carbene species from cyclic vinyl iodoniums was hypothesized

  • •

    Flexible transformations to build up chemical library through DOS strategy

Chemistry; Catalysis; Organic Chemistry; Organic Synthesis

Introduction

Cross-coupling reactions have become one of the most effective synthetic methods for constructing chemical bonds and linking molecular fragments (Liu et al., 2011). The traditional cross-coupling reactions between aryl iodide and nucleophiles are often transition-metal catalyzed, for example, Heck, Ullmann, and Suzuki-Miyaura cross-couplings (Evano et al., 2008; Ruiz-Castillo and Buchwald, 2016). The bond cleavage of C-I in aryl iodide to make new bonds often requires high-temperature, transition-metal catalysis, and long reaction time (Figure 1A) (Biffis et al., 2018). To overcome such limitations, new reactants and methods are demanded to enable coupling reactions more conveniently (Sun and Shi, 2014). Hypervalent aryl iodine(III), also called aryliodonium(III), has increased the reactivity of C-I bond to make coupling reactions easier (Lukamto and Gaunt, 2017; Merritt and Olofsson, 2009; Teskey et al., 2017; Yoshimura and Zhdankin, 2016). Compared with linear aryliodoniums, cyclic diaryliodoniums (cDAIs) are more atom economical in their coupling reactions. cDAIs are able to react with a broad range of reagents and to construct diverse multi-aromatic fragments that often exist in drugs and natural products (Mathew et al., 2017; Zhu et al., 2018). However, some innate defects of cDAIs particularly including the reliance on catalytic metal (Chatterjee and Goswami, 2017; Hu et al., 2019) and poor regioselectivity (Deprez and Sanford, 2009; Liu et al., 2014), limit their synthetic applications (Figure 1B). Breaking the diaryl framework of cDAIs, cyclic monoaryl-vinyl iodoniums (cMAVIs) could be conceived. In this new framework, the hypervalent iodine is structurally asymmetrical and unbalanced in charge distribution, which may enhance the reaction regioselectivity. Furthermore, compared with cDAIs, the deficient electron density of the hypervalent iodine in cMAVIs is not easy to offset in the monoaryl-vinyl system, rendering them highly electrophilic. However, cMAVIs are almost unexplored until very recently Moran and co-workers reported the synthesis of cMAVIs with limited chemical study (Beringer et al., 1972; Kepski et al., 2019). Herein, we report a special series of cMAVIs that could be finely tuned to react with various nucleophilic reagents regioselectively, enabling the rapid construction of C-N, C-O, and C-C bond under metal-free conditions via a carbene pathway (Figure 1C).

Figure 1.

Figure 1

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Development of Cyclic Monoaryl-Vinyl Iodoniums

(A) Aryl iodides couple with nucleophiles via transition-metal catalysis.

(B) Cyclic diaryliodoniums couple with nucleophiles via transition-metal catalysis in moderate conditions.

(C) Cyclic monoaryl-vinyl iodoniums couple with nucleophiles without transition-metal in carbene pathway.

Results and Discussion

The Design of New cMAVIs and Their Reactivity Study

To commence our study, four types of cMAVIs have been designed (Figure 2A). While a carbonyl group was installed to stabilize the iodine charge, various R groups were taken into consideration to test its impact on chemical properties, including alkyl (1a), aryl (1b), halogen (1c), and hydrogen (1d). After the preparation of precursors 1′ of cMAVIs (see Supplemental Information) (Ho et al., 2007; Puri et al., 2014; Roy et al., 2011), cMAVIs 1a-1d were obtained in good yields using the procedure for the synthesis of cDAIs (Zhu et al., 2013). The crystal X-ray diffraction unambiguously verified the structure of 1a. With these four cMAVIs at hand, we tested their stability under various conditions (Table S1). The cMAVIs were all stable in either powder or solution at room temperature and even under heating. However, in the presence of triethylamine, cMAVIs 1a-1c underwent a reductive ring opening to produce 3a-3c. Meanwhile, 1d had β-hydrogen elimination ring opening, which is consistent with Moran's report (Figures 2B and S1) (Kepski et al., 2019). The newly obtained results indicated that these cMAVIs were vulnerable to triethylamine. On the other hand, their instability to bases implied that they might be highly reactive even without a transition metal, which is unusual for traditional cDAIs (Li et al., 2019; Wu and Yoshikai, 2015). It would be valuable if their reactivity could be tuned under refined conditions. Meanwhile, the iodine moving to the aryl side in the reductive products 3 implied that an excellent regioselectivity with cMAVIs could be achieved, which is challenging in unsymmetrical cDAIs. Thus, we hypothesized that our synthesized cMAVIs might provide a synthon platform and achieve the complete regioselectivity under transition-metal-free condition, which is highly demanded in the field of synthetic chemistry (Ellwart et al., 2016).

Figure 2.

Figure 2

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Exploration of New cMAVIs and Their Reactivity

(A) The structure of novel cMAVIs with different substitutes on β-position.

(B) Amination of 1a with p-toluidine under activation of Et3N.

(C) Condition optimization of the coupling amination between 1a and p-toluidine.

(D) The structure of 1a-alike cMAVIs.

TEA, triethylamine; DIPEA, N,N-diisopropylethylamine; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DMF, N,N-dimethylformamide; THF, tetrahydrofuran.

Considering that triethylamine is a strong organic base, p-toluidine with weak basicity was employed to test whether it could undergo amination with cMAVIs. In the presence of p-toluidine only, 1a-1c remained intact, although 1d still led to the β-hydrogen elimination, implying that activation of 1a-1c could be initiated by trimethylamine but not p-toluidine. While both triethylamine and p-toluidine were added into the solution of cMAVIs, a new C-N bond was formed rapidly to provide the amination product 4a at an excellent yield (Figure 2B). The iodine was located to the aryl side, and p-toluidine was linked to the vinyl side selectively. Moreover, the internal C-C double bond unexpectedly migrated to the adjacent methyl. Such amination did not happen in cMAVIs 1b and 1c, and only reductive products 3b and 3c remained (Figure S1). After the success of 1a attached with a methyl group, ethyl was also tested. However, the cMAVI with ethyl could not fulfill this amination and it almost converted to 3a-like reductive product, likely due to its spatial effect. Meanwhile, 1a was under thorough investigation to optimize the amination condition. Further screening demonstrated that organic bases including triethylamine and diisopropyl ethylamine were most effective (Figure 2C). Environment-friendly solvent EtOH and THF were as effective as dichloromethane, so they were selected in further study. Variation of temperature did not compromise the amination yields. After success in tuning cMAVI 1a to react with p-toluidine in complete regioselectivity under metal-free condition, a series of 1a-alike cMAVIs were designed and synthesized (Figure 2D).

The Exploration of Coupling Reactions with 1a-alike cMAVIs

As the optimal condition for the coupling amination of cMAVI 1a with p-toluidine was obtained, the scope of both cMAVIs and amines was investigated (Figure 3A). 1a-alike cMAVIs (1ab-1ag) underwent amination smoothly to provide desired compounds 4aa-4ag at excellent yields. Simultaneously, the vinyl migration to the terminal methyl proceeded. Then, the scope of anilines was also tested to further explore the transformation generality. It turned out that not only simple aniline but also the sterically hindered anilines with an ortho substituent reacted well (4ah-4al). The acetylene group was well tolerated in this reaction (4ak), although terminal acetylenes reportedly react with traditional cDAIs (Xie et al., 2017). The structure of 4ak was further unambiguously verified by X-ray diffraction. It is worth mentioning that amidation of benzene-1,2-diamine with the intramolecular ester of 1a simultaneously proceeded along with conventional amination to make 4al. N-substituted methyl group was also allowed to provide 4am. Furthermore, benzylamines were suitable substrates for such amination as well while the reactions were done in THF (4an and 4ao). Other alkylamines did not provide the desired products, most likely due to their strong basicity. As azoles could be employed as N-nucleophiles and important heterocyclic fragments (Sun et al, 2015, 2020), benzotriazole was used to investigate the transformation. However, the double bond in the coupling product remained internal, likely due to strong electron-withdrawing effect of the triazole motif (data not shown).

Figure 3.

Figure 3

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Scope of 1a-Alike cMAVIs and Nucleophiles in Transition-Metal-Free Coupling Reaction

(A) Scope of 1a-alike cMAVIs and N-nucleophiles.

(B) Scope of O-nucleophiles coupled with 1a

(C) Scope of C-nucleophile coupled with 1a.

Note: standard condition: 1 (1.0 equiv), 2 (1.5 equiv), Et3N (2.0 equiv), EtOH, r.t., 30 min; isolated yields. a1 gram scale reaction for 1a; b12 h; c in THF; din THF, Et3N (3.5 equiv); unless stated, R1, R2 are H.

After the amination success, we went to test whether coupling reactions with other nucleophiles would be possible under such metal-free condition. Initially, O-nucleophiles were taken into consideration for potential oxygenation of cMAVIs (Figure 3B). Phenol was chosen to react with 1a under the standard condition but with THF as the solvent due to a potential breakup of the newly formed ester bond by ethanol. The oxygenation product 4ba was indeed successfully obtained at a moderate yield. Vinyl migration to the terminal methyl took place simultaneously. Other phenols substituted with various functional groups also gave the desired products at moderate to good yields (4bb-4bf). Benzoic acids, another type of O-nucleophiles (Kitano et al., 2018; Petersen et al., 2011), were suitable substrates to couple with 1a, albeit at slightly low yields (4bg-4bi). Aromatic α, β-unsaturated acids such as phenylpropiolic acid and cinnamic acid also gave the desired coupling products (4bj-4bk). However, alkyl carboxylic acids failed to undergo such oxygenation. Generally, it seemed that hard nucleophiles gave lower yields in the coupling reactions.

As indole fragment, a mild C-nucleophile (Leitch et al., 2017; Lin et al., 2019), is widely present in natural products and pharmaceuticals (Kochanowska-Karamyan and Hamann, 2010; Wan et al., 2019), its potential C-C bond formation with cMAVIs under the metal-free condition was of our interest. First, simple indole itself was tested under the standard condition and satisfactorily gave the desired product 4ca with C-C formation at 3-position of indole (Figure 3C). Other indole derivatives with methyl substitution on different positions were then investigated to expand the reaction generality. Except 3-methyl indole, the other tested indoles underwent the C-C coupling reaction successfully (4cb-4ce), implying that the C-C coupling reaction proceeded at 3-position of indole under our condition (Modha and Greaney, 2015). The successful reaction with indole demonstrated that cMAVIs were highly reactive at room temperature under catalyst-free conditions, although the yields were not satisfactory.

Coupling Reactions Utilized to Construct Chemical Libraries

Under these aforementioned explorations, we successfully tuned these novel highly reactive cMAVIs to rapidly couple with aniline, phenol, aromatic acid, and indole under transition-metal-free conditions with complete regioselectivity. Diversity-oriented synthesis (DOS) is an efficient strategy to quickly offer a large collection of structurally diverse small molecules for drug discovery (Grossmann et al., 2014). It was also our interest to employ DOS strategy to build chemical libraries. Starting from 1a and 1a-alike cMAVIs, our structurally diversified coupling products 4 could be transformed into different series of heterocyclic fragments (Figure 4). 4aa-4ag underwent palladium-catalyzed intracellular C-N formation to accomplish the indole ring construction in series 1 compounds (5a-5g) (Bugaenko et al., 2018; Ignatenko et al., 2010). Meanwhile, the terminal vinyl double bond in 4aa could be used as an acceptor for halogenation (Meimetis et al., 2014; Song et al., 2013). Then, NBS was utilized to assemble 2-substituted 3-quaternary carbon-centered indole 6 that is not easily prepared via conventional methods (series 2) (Golubev and Krasavin, 2017). As mentioned earlier, ortho-substituted functional groups in anilines were well tolerated in the amination (Figure 3, 4ai-4al). Moreover, these groups were able to participate in further transformation so that more series of heterocyclic fragments could be obtained. The condition used for the construction of series 1 compounds also enabled 4ai to finish the formation of two rings featuring 5 and 7 members (7, series 3). Ortho-bromo-substituted 4ao and alike derivatives could undergo double C-C bond formations to build up 5- and 6-membered rings (8a-8d, series 4) (Gómez-Lor and Echavarren, 2004; Rousseaux et al., 2010). Ortho-boronic acid functional group in anilines was also compatible for the amination; however, it was labile during the silica column chromatography. Without further purification, these obtained intermediates 4 were directly subjected to a palladium-mediated condition. Consequently, a specific azepine scaffolding, which is an important structural subunit in many bioactive alkaloids and medicines (Poulie and Bunch, 2013; Singh et al., 2017), was constructed successfully at moderate yields (9a-9d, series 5). Indole-incorporating compound 4ca could undergo a palladium-catalyzed cyclization to provide a specific carbazole fragment (10, series 6). Taken together, six series of chemical fragments are rapidly built from our developed cMAVIs in two steps. These high-quality fragments are demanded in the drug discovery, especially in the fragment-based approaches (Alen et al., 2019; Heightman et al., 2018; Kirsch et al., 2019).

Figure 4.

Figure 4

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DOS Strategy Applied to Construct Heterocyclic Fragments from 1a and 1a-Alike cMAVIs

Note: Unless stated, otherwise R, R1, and R2 stand for H; DCE, 1,2-dichloroethane; NBS, N-bromosuccinimide.

Coupling Reactions' Mechanism Study

Due to the observation of vinyl migration, we hypothesized that carbene pathway might be involved (Dempsey Hyatt et al., 2015; Hyatt and Croatt, 2012; Kepski et al., 2019). A series of experiments were performed to test our hypothesis. Deuterated p-toluidine was employed to react with cMAVI 1a. Indeed α-deuterium is present in product 11-D (Figure 5A), confirming the possible presence of carbene intermediate species. It is worth mentioning that 11-H with α-hydrogen verified by 1HNMR spectra likely resulted from a hydrogen-deuterium exchange with the abstracted protons from 1a′s methyl by triethylamine. In another control experiment in which styrene was added, a cyclopropane product 12 in the reaction mixture was detected by liquid chromatography-mass spectrometry (MS)spectroscopy showing a mass ion peak at 433.1 (Figure 5B), further confirming the appearance of carbene species. On subjection of 1a to EtOH as solvent in the absence of additional nucleophiles, compound 13 was observed and confirmed by NMR (Figure 5C) (Hyatt and Croatt, 2012). Based on these observations, a potential mechanism of the reactions was proposed (Figure 5E). After hydrogen abstraction in methyl from a base, internal double bond of cMAVI 1a would migrate to the terminal to form ylide species A1 (Ivanov et al., 2014). Reversible conversion into carbene species A2 initiated the forthcoming nucleophilic insertion of a nucleophile (Ar-XH) to quickly generate 4. Without competitive nucleophile, A2 would couple with Et3N to produce an ylide salt B, and B tended to rearrange into an ammonium salt C. Finally, C underwent two-electron transfer from the triethylamino motif that underwent β-H elimination to provide 3a. The formation of oxidative species D was confirmed by gas chromatography-MS (Figure S2). However, the exact mechanism remains to be fully elucidated. With other groups instead of methyl, 1b and 1c might undergo a direct nucleophilic attack from triethylamine to form F that is similar to C, and 3b and 3c were then formed (Figure S3).

Figure 5.

Figure 5

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The Mechanism Studies

(A) The insertion of deuterated aniline.

(B) The cycloaddition with 4-methyl styrene.

(C) The insertion of EtOH.

(D) A proposed mechanism to generate 4 and 3a.

Conclusion

In summary, we have developed a series of novel cyclic monoaryl-vinyl iodoniums that are highly reactive. These unique iodonium species have been well tuned to couple with various nucleophiles including aniline, phenol, aromatic acid, and indole, constructing C-N, C-O, and C-C bonds regioselectively without metal catalysis. Activated by organic bases represented by triethylamine, the reactions are performed in environment-friendly solvents EtOH and THF at ambient temperature. Moreover, the coupling products allow further diversification. Six series of chemical libraries are quickly built via a DOS strategy, providing high-quality drug-like fragments that are desirable in the drug discovery field. In the mechanism study, we propose that these cMAVIs can be employed as a new source to generate carbene species, which would open a venue to accomplish diverse transformations.

Limitations of the Study

In our current work, alkyl amines and alkyl carboxylic acids are not suitable substrates to realize the coupling reactions.

Resource Availability

Lead Contact

Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Shijun Wen (wenshj@sysucc.org.cn).

Materials Availability

This study generated new unique reagents, cyclic monoaryl-vinyl iodoniums.

Data and Code Availability

The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Center (1a: 1893710, 4ak: 1972497). These data could be obtained free of charge from The Cambridge Crystallographic Data Center via https://www.ccdc.cam.ac.uk/structures/. Original data in this paper have been deposited to Research Data Deposit (https://www.researchdata.org.cn) with a RDD number of RDDB2020000876.

Methods

All methods can be found in the accompanying Transparent Methods supplemental file.

Acknowledgments

This work was supported by National Natural Science Foundation of China (81672952, 81872440), Guangdong Science and Technology Program (2017A020215198), and Guangzhou Science and Technology Program (201807010041).

Author Contributions

H.W. and S.W. conceived the study; H.W. carried out most of the reaction and analyzed the data. H.W., S.W., L.L., Z.G., H.P., S.Q., N.S., D.Z., W.Z., and P.H. prepared the manuscript and Supplemental Information; Y.C. collected and analyzed the crystallographic data. All authors discussed the results and commented on the manuscript.

Declaration of Interests

The authors declare no competing interests.

Published: July 24, 2020

Footnotes

Supplemental Information can be found online at https://doi.org/10.1016/j.isci.2020.101307.

Contributor Information

Peng Huang, Email: huangpeng@sysucc.org.cn.

Shijun Wen, Email: wenshj@sysucc.org.cn.

Supplemental Information

Document S1. Transparent Methods, Figures S1–S3, Table S1, and Data S1
mmc1.pdf (10.3MB, pdf)

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Document S1. Transparent Methods, Figures S1–S3, Table S1, and Data S1
mmc1.pdf (10.3MB, pdf)

Data Availability Statement

The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Center (1a: 1893710, 4ak: 1972497). These data could be obtained free of charge from The Cambridge Crystallographic Data Center via https://www.ccdc.cam.ac.uk/structures/. Original data in this paper have been deposited to Research Data Deposit (https://www.researchdata.org.cn) with a RDD number of RDDB2020000876.

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