KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, Peptides, and Recombinant Proteins
TO1-Biotin	Ref Dolgosheina 2014	N/A
Thiazole orange	Sigma-Aldrich	17237
TO1-Acetate	Ref Dolgosheina 2014	N/A
TO1-CMPD1	Ref Dolgosheina 2014	N/A
TO1-CMPD2	Ref Dolgosheina 2014	N/A
TO1-ME	Ref Trachman 2018	N/A
TO1-PE	Ref Trachman 2018	N/A
TO3-Biotin	Ref Dolgosheina 2014	N/A
YO3-Biotin	Jepsen et al. 2018	N/A
Deposited Data
Mango-IV-TO1-Biotin (native)	This study	6V9D
Mango-IV-TO1-Biotin (Br derivative)	This study	6V9B
Oligonucleotides
See Supplementary Table 3
Software and Algorithms
HKL2000	Otwinowski and Minor, 1997	http://www.hkl-xray.com/
XDS	Kabsch, 2010 b	http://xds.mpimf-heidelberg.mpg.de/
DIALS	Winter et al., 2018	http://dials.github.io/
Phenix	Adams et al., 2010	https://www.phenix-online.org/
Coot	Emsley and Cowtan, 2004	https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/
Pymol	DeLano, 2002	https://pymol.org/2/
SednterpPymol	Laue, et al., 1992 DeLano, 2002	http://www.jphilo.mailway.com/download.htmhttps://pymol.org/2/
SEDFIT	Peter Schuck, 2019	https://sedfitsedphat.nibib.nih.gov/software/default.aspx