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Human papillomavirus (HPV) E6 and E7 mediated regulation of methyltransferase activity. P53 inactivation by E6 leads to decreased Sp1 transcriptional factor inactivation, allowing increased DNMT1 transcription. E7-mediated downregulation of retinoblastoma protein hinders E2F sequestration. This E2F upsurge further promotes DNMT1 expression. E7 binds with DNMT1 to form the E7/DNMT1 complex, promoting DNMT1 activity.
