Table 2.
Patients’ characteristics according to SPARC methylation status (methylated/unmethylated).
| Characteristics | SPARC Unmethylated | SPARC Methylated | p-Value * |
|---|---|---|---|
| n | 23 | 36 | |
| Age at Diagnosis (mean yy ± SD) | 67.5 ± 8.7 | 67.8 ± 8.3 | 0.704 |
| Gender (n, %) | 0.726 | ||
| Male | 19 (82.6) | 31 (86.1) | |
| Female | 4 (17.4) | 5 (13.9) | |
| Smoking Status (n, %) | 0.741 | ||
| Smoker | 10 (43.5) | 18 (50.0) | |
| Never smoker | 3 (13.0) | 3 (8.3) | |
| Former smoker | 10 (43.5) | 15 (41.7) | |
| Disease Stage | 0.936 | ||
| IA/B | 11 (47.8) | 17 (47.2) | |
| IIA/B | 5 (21.7) | 9 (25.0) | |
| IIIA/B | 4 (17.4) | 7 (19.5) | |
| IV | 3 (13.1) | 3 (8.3) | |
| pT § (n, %) | 0.604 | ||
| T1 | 7 (30.4) | 13 (36.1) | |
| T2 | 12 (52.2) | 15 (41.7) | |
| T3 | 1 (4.4) | 5 (13.9) | |
| T4 | 3 (13.0) | 3 (8.3) | |
| pN (n, %) | 0.701 | ||
| N0 | 16 (69.6) | 26 (72.2) | |
| N1 | 5 (21.7) | 5 (13.9) | |
| N2 | 2 (8.7) | 5 (13.9) | |
| pM (n, %) | 0.369 | ||
| M0 | 20 (87.0) | 34 (94.4) | |
| M1 | 3 (13.0) | 2 (5.6) | |
| Histology | 0.423 | ||
| ADC | 15 (65.2) | 19 (52.8) | |
| SqCC | 8 (34.8) | 17 (47.2) | |
| KRAS Status § | 1.000 | ||
| Wild-type | 18 (90.0) | 29 (90.6) | |
| Mutated | 2 (10.0) | 3 (9.4) | |
| Missing data | 3 | 4 |
ADC, adenocarcinoma; SqCC, squamous cell carcinoma; yy, years; SD, standard deviation. * p-values from Mann-Whitney U test or Fisher exact test for continuous and categorical variables, respectively; § patients with missing values were not considered.