Lactobacillus plantarum ZS2058 (ZS2058) and eugenol muted the lethal effect of Salmonella in mice. Mice were pre-treated with regular diet and phosphate buffer saline (ST), regular diet and ZS2058 (Z), eugenol-contained diet and PBS (E), or eugenol-contained diet and ZS2058 (ZE) for 10 days before Salmonella infection. The control mice (C) were also pre-treated with regular diet and PBS but were not infected. Survival of mice was observed and recorded daily for 20 days. n = 30, group ZE versus group ST, p = 0.026; group Z versus group ST, no significance; group E versus group ST, no significance.