Figure 5.

Infectious virus is consistently detected in fecal samples from chronically infected patients. (a) Levels of infectious virus detected in HEK293T cells inoculated with human norovirus genotypes, according to capsid (ORF2) and polymerase (ORF1) genotypes. The shaded boxes indicate samples with the same polymerase (ORF1) genotype. Three patients (Patients 7, 12, and 1) did not have detectable infectious virus in any of the samples tested, and one patient did not have any after the initial sample collection. (b) Infectivity of different noroviruses subdivided by GI and GII genogroups and by different ORF1 and ORF2 genotypes. The dashed line represents the lower limit of detection. Error bars indicate SEM values. Data represent the averages from 2 independent experiments.