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. 2020 Jun 3;12(6):609. doi: 10.3390/v12060609

Figure 8.

Figure 8

Combinations of LRAs induce gp120 expression in latently infected cells. OM-10.1 cells (a,b) and ACH-2 cells (c,d) were treated with LRAs alone or in combination and analyzed for gp120 expression following 24 h and 48 h treatment. OM-10.1 positive control cells were treated with PMA or TNFα. ACH-2 positive control cells were treated with PMA. Cells were incubated with anti-HIV-1 gp120 mAb VRC03, and the gp120 expression was evaluated using flow cytometry by gating on live cells. The percentage of positive cells was reported. Red columns represent cells treated with prostratin in combination with or without HDACis; green columns are cells treated with TPPB in combination with or without HDACis; blue columns are cells treated with indolactam in combination with or without HDACis; and white columns are cells treated with a single HDACi. Data are shown as mean ± S.D. of three independent experiments.