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. 2020 Jun 5;12(6):516. doi: 10.3390/pharmaceutics12060516

Figure 4.

Figure 4

(A) Diagram of the PermeGear Franz diffusion cell system. PBS is warmed to 37 °C before being pumped into the donor compartment, underneath the skin, and finally resides in the scintillation vial, which was changed hourly. (B1,B2) UV-Vis comparing the amount of miconazole located within the stratum corneum and lower dermal layers after 24 h in the PermeGear diffusion system. (C1,C2) Hourly readings of the PBS collected scintillation vials, identifying the amount of drug that may pass completely through the skin and into the bloodstream within 24 h. All data are presented as mean ± SE (n = 6). *p < 0.05; **p < 0.01 compared with the Actavis.