Table 2.
Synergy test on methicillin-resistant Staphylococcus aureus (MRSA) USA300, two-fold dilution series of both antibiotics and CBD, 128–0.5 µg/mL and 16–0.25 µg/mL, respectively. FICindex ≤ 0.5 is considered synergy; FICindex between 0.5 and 1 is considered additive; FICindex between 1 and 4 is considered indifferent; and FICindex ≥ 4 is considered antagonist.
| Drug Combination | FICindex |
|---|---|
| CBD + Clindamycin | 1.03 |
| CBD + Vancomycin | 1.13 |
| CBD + Tobramycin | 1.50 |
| CBD + Teicoplanin | 1.13 |
| CBD + Ofloxacin | 1.50 |
| CBD + Methicillin | 1.25 |
| CBD + Meropenem | 1.13 |
FIC: fractional inhibitory concentration.