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IRE1α inhibition by 4µ8C in hypoxia (6 h) results in HIF-1α protein reduction in (A) HMVECs-C and (B) HAECs. HIF-1α protein levels after IRE1α inhibition by 4µ8C in normoxia and hypoxia were evaluated by Western Blotting, normalized to β-actin and total protein levels and related to hypoxia (CTRL). The densitometry analysis is representing two independent experiments (* p < 0.05 was considered significant).
