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. 2020 Jun 17;12(6):561. doi: 10.3390/pharmaceutics12060561

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biocompatibility assays for magnetite/silver (blue), magnetite/silver-pDMAEMA (red) and magnetite/silver-pDMAEMA-PEA-BUFII (green). LP represents free liposomes and MLP magnetoliposomes. (A) Cytotoxicity by LDH in Vero cells line after 24 h. (B) Cytotoxicity by LDH in Vero cells after 48 h. Except for MLP, cell viability remained above 95%. (C) The hemolysis assay shows an average hemolytic effect below 9% in all cases. The positive control was Triton 100-X. (D) Platelet aggregation assay shows an aggregation tendency of about 40% for all treatments. The negative control was PBS 1X, while the positive one was thrombin.