Table 6.

Skin corrosion and irritation category and subcategories according to the Globally Harmonized System of Classification and Labelling Chemicals (GHS).

Corrosion
Categories	Criteria
Category 1	Destruction of skin tissue in which necrosis of epidermis was observed in at least one tested animal after ≤4 h of exposure
Subcategory 1A	Skin corrosion in at least one tested animal at an exposure of ≤3 min upon removal of the test patch (observation period: ≤1 h)
Subcategory 1B	Skin corrosion in at least one tested animal at an exposure of >3 min and ≤1 h upon removal of the test patch (observation period: ≤14 days)
Subcategory 1C	Skin corrosion in at least one tested animal at an exposure of >1 h and ≤4 h upon removal of the test patch (observation period: ≤14 days)
Irritation
Categories	Criteria
Irritation (Category 2)	Erythema and edema with a score of ≥2.3 and ≤4.0 in at least 2 out of 3 tested animals after 24, 48 and 72 h after removal of the test patch.
Mild irritation (Category 3)	Erythema and edema with a score of ≥1.5 and ≤2.3 in at least 2 out of 3 tested animals after 24, 48 and 72 h after removal of the test patch.