Figure 2.

Clinical conditions following NAP treatment of C. jejuni infected secondary abiotic IL10^−/− mice. On day (d) 0 and d1 secondary abiotic IL10^−/− mice were perorally infected with C. jejuni strain 81–176 by gavage and treated intraperitoneally with either synthetic NAP (open circles) or placebo (PLC; closed circles) from d2 until d5. On d6 post-infection, (A) the overall clinical conditions, (B) wasting, (C) fecal blood, and (D) stool consistency were quantitatively assessed applying a standardized clinical scoring system. Naive mice served as negative controls (open diamonds). Medians (black bars), levels of significance (p-values) as determined by the Kruskal–Wallis test and Dunn’s post-correction and number of analyzed animals (in parentheses) are given. Data were pooled from four independent experiments.