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Cancer Cell International logoLink to Cancer Cell International
. 2020 Jul 14;20:308. doi: 10.1186/s12935-020-01408-3

Correction to: Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

Rustelle Janse van Vuuren 1, Mandie Botes 1,2, Tamarin Jurgens 1, Anna Margaretha Joubert 1, Iman van den Bout 1,2,
PMCID: PMC7359456  PMID: 32684845

Correction to: Cancer Cell Int (2019) 19:1 10.1186/s12935-018-0719-4

Following publication of the original article [1], the authors notified us that the graph presented in Figure 3a is the same as Figure 2a in the published manuscript. Figure 3 below represents the true migration values achieved for cells blocked in interphase and treated with the different compounds.

Fig. 3.

Fig. 3

Migration of interphase arrested cells is inhibited by ESE-15-one and ESE-one exposure. a MDA-MB-231 cells were first blocked in G1/S by exposure to thymidine before cell free zones were generated and cells were exposed to 0.2% DMSO, 0.5 μM ESE-15-one or 0.5 μM ESE-one. Cell migration into the cell-free zone was quantified after 18 h. The graph represents the average of at least three repeats with error bars representing SEM. *P < 0.001 in t-test comparison with DMSO-treated cells. b Light microscopy images of cell migration assays showing interphase cells at time 0 h and after 18 h treated with DMSO, ESE-15-one or ESE-one. Scale bar is 400 μm

Specifically, blocked cells treated with DMSO closed 35% of the wound while ESE-15-one reduced that to 23% and ESE one reduced this to 13%. T tests show statistical significance.

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Reference

  • 1.van Vuuren RJ, Botes M, Jurgens T, Joubert AM, van den Bout I. Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization. Cancer Cell Int. 2019;19:1. doi: 10.1186/s12935-018-0719-4. [DOI] [PMC free article] [PubMed] [Google Scholar]

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