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. 2020 Jun 19;7(3):ENEURO.0024-20.2020. doi: 10.1523/ENEURO.0024-20.2020

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Copyright © 2020 Arias-Cavieres et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — IH enhances protein carbonyl content and increase NOX4 expression in wild type but not in HIF1a^+/−. A, Hippocampal homogenates from control (n = 4), IH₁₀ (n = 4), 0-HIF1a^+/− (n = 4), and 10-HIF1a^+/− (n = 4). While IH₁₀ displayed elevated protein, carbonyl content was not elevated in either 0-HIF1a^+/− or 10-HIF1a^+/−. B, Comparison of the pro-oxidant enzyme, NOX4, from control (n = 5), IH₁₀ (n = 5), 0-HIF1a^+/− (n = 5), and 10-HIF1a^+/− (n = 5) reveals that NOX4 is increased in IH₁₀; p < 0.01), but not elevated in either 0-HIF1a^+/− or 10-HIF1a^+/−; **p < 0.01; N.S., p > 0.05.