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. 2020 Jun 24;143(7):2039–2057. doi: 10.1093/brain/awaa147

Figure 2.

Figure 2

Seizure susceptibility of Grin2aS644G mice. (A) Survival curve showing the rate and onset between postnatal Days 15 and 17 of S644G genotype-dependent in F2 hybrid male and female mice. (B and C) Heterozygous (het) adult mice have lower seizure threshold in minimal seizure end points (female: n = 20 wild-type, n = 22 het, P = 0.0048; male: n = 31 wild-type, n = 27 het, P = 0.0035); and maximal seizure ECT end-points (female: n = 6 het, n = 7 wild-type; P = 0.0434; male: n = 15 het, n = 9 wild-type; P = 0.0007), but (D) are significantly more resistant to partial seizures in the 6 Hz ECT test (sexes combined: n = 33 het, n = 31 wild-type; P = 4.1 × 10−12); Mann-Whitney rank-sum test. (E) Significantly decreased tonic-clonic seizure incidence in S644G/+ mice (n = 12; five males, seven females) compared to wild-type mice (n = 12; six males, six females) following subcutaneous injection of 45 mg/kg PTZ (P = 0.0006, two-tailed Fisher's exact test). Error bars are quartiles. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. iRMS = integrated root mean square.