In Table 1, the data and footnotes use an outdated analysis and do not correctly describe the contents of the table. Please see the correct Table 1 here.
Table 1. Classification of bacteriologically confirmed cases according to expert panel decision.
Xpert result a | Culture result b | Chest X-ray c | TB treatment history d | Number of cases |
---|---|---|---|---|
MTB detected | MTB Growth | Any | Any | 130 e |
MTB not detected | MTB Growth | Abnormal | Any | 48 |
MTB detected | No growth | Abnormal | No history | 34 |
MTB detected | No growth | Abnormal | < 2 years | 2 |
MTB detected | No growth | Abnormal | > 2 years | 3 |
MTB detected | Contaminated/missing/NTM | Abnormal | No history | 4 |
MTB detected | Contaminated/missing/NTM | Abnormal | < 2 years | 0 |
MTB detected | Contaminated/missing/NTM | Abnormal | > 2 years | 0 |
Total number | 221 |
MTB: Mycobacterium tuberculosis; NTM: Nontuberculous mycobacteria
a Combined result of two Xpert tests on different sputum sample (M1 and M1b). Does include participants with one (n = 55) and two (n = 118) Xpert results of MTB detected
b Final culture result, which is the MGIT result unless the MGIT culture was contaminated and the LJ culture result was either no growth or MTB+, then the LJ result was taken (n = 1)
c Final expert panel conclusion, abnormal meaning chest X-ray with any abnormality suggesting active TB disease
d Treatment history as reported by the participant in the in-depth interview
e Five of these patients were on TB treatment at the time of the survey, and five reported to have TB treatment history within two years preceding the survey.
In Table 2 and Table 4, the headings Rural and Remote are swapped in the fifteenth and sixteenth rows. The fifteenth row should be Remote and the sixteenth row should be Rural. Please see the correct Table 2 and Table 4 here.
Table 2. Screening outcomes of the survey, by sex, age, area, and region.
Total screened participants | Total screening positive | Interview a screening positive only | Chest X-ray screening positive only | Both interview and chest X-ray positive | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | % | p-value | No. | % | p-value | No. | % | p-value | No. | % | p-value | ||
Total | 61,163 | 4,738 | 7.7 | 2,207 | 3.6 | 1,849 | 3.0 | 682 | 1.1 | ||||
Sex | <0.001 | <0.001 | <0.001 | <0.001 | |||||||||
Male | 27,150 | 2,842 | 10.5 | 1,272 | 4.7 | 1,088 | 4.0 | 482 | 1.8 | ||||
Female | 34,613 | 1,896 | 5.5 | 935 | 2.7 | 761 | 2.2 | 200 | 0.6 | ||||
Age group | <0.001b | <0.001b | <0.001b | <0.001b | |||||||||
15–24 | 6,542 | 135 | 2.1 | <0.001c | 99 | 1.5 | <0.001c | 27 | 0.4 | <0.001c | 9 | 0.1 | <0.001c |
25–34 | 10,191 | 379 | 3.7 | <0.001c | 253 | 2.5 | <0.001c | 84 | 0.8 | <0.001c | 42 | 0.4 | <0.001c |
35–44 | 11,508 | 577 | 5.0 | <0.001c | 360 | 3.1 | 0.004c | 160 | 1.4 | <0.001c | 57 | 0.5 | <0.001c |
45–54 | 13,289 | 1,074 | 8.1 | 0.045c | 565 | 4.3 | <0.001c | 370 | 2.8 | 0.110c | 139 | 1.1 | 0.468c |
55–64 | 11,143 | 1,193 | 10.7 | <0.001c | 529 | 4.8 | <0.001c | 494 | 4.4 | <0.001c | 170 | 1.5 | <0.001c |
≥ 65 | 9,090 | 1,380 | 15.2 | <0.001c | 401 | 4.4 | <0.001c | 714 | 7.9 | <0.001c | 265 | 2.9 | <0.001c |
Area | 0.383 | <0.001 | <0.001 | <0.001 | |||||||||
Urban | 18,656 | 1,415 | 7.6 | 0.595c | 487 | 2.6 | <0.001c | 710 | 3.8 | <0.001c | 218 | 1.2 | 0.314c |
Remote | 15,882 | 1,216 | 7.7 | 0.935c | 692 | 4.4 | <0.001c | 403 | 2.5 | <0.001c | 121 | 0.8 | <0.001c |
Rural | 27,225 | 2,107 | 7.7 | 0.537c | 1,028 | 3.8 | 0.016c | 736 | 2.7 | <0.001c | 343 | 1.3 | 0.001c |
Region | <0.001 | <0.001 | <0.001 | <0.001 | |||||||||
North | 25,575 | 1,917 | 7.5 | <0.001c | 1,094 | 4.3 | <0.001c | 639 | 2.5 | <0.001c | 184 | 0.7 | <0.001c |
Central | 13,525 | 1,216 | 9.0 | 0.168c | 531 | 3.9 | <0.001c | 391 | 2.9 | 0.428c | 294 | 2.2 | <0.001c |
South | 22,663 | 1,605 | 7.1 | <0.001c | 582 | 2.6 | 0.012c | 819 | 3.6 | <0.001c | 204 | 0.9 | <0.001c |
No: number of participants with such characteristics
a Including those who reported TB symptoms and/or TB treatment history, defined as follows:
TB symptoms: cough for 2 weeks or more, or cough of any duration in pregnant women.
Treatment history: currently on TB treatment or reporting TB treatment in the 2 years preceding the survey
b p-value for trend, obtained by rank-sum test
c p-value for the difference between this age group/ area/ region with other groups combined, obtained by Pearson’s chi-squared test
Table 4. Estimated prevalence of pulmonary tuberculosis in Vietnam, overall and by sex, age, area and region.
Smear-positive TB | Xpert-positive TB | Bacteriologically confirmed TB | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of participants | No. of cases | Crude prevalence (per 100,000) n (95% CI) |
Weighted prevalence (per 100,000)a n (95% CI) |
p-value | No. of cases | Crude prevalence (per 100,000) n (95% CI) |
Weighted prevalence (per 100,000)a n (95% CI) |
p-value | No. of cases | Crude prevalence (per 100,000) n (95% CI) |
Weighted prevalence (per 100,000)a n (95% CI) |
p-value | |
Total | 61,763 | 50 | 81 (61–107) | 79 (55–115) | 173 | 280 (241–325) | 235 (187–296) | 221 | 358 (314–408) | 322 (260–399) | |||
Sex | 0.004 | <0.001 | <0.001 | ||||||||||
Male | 27,150 | 34 | 125 (89–175) | 118 (78–180) | 138 | 508 (430–600) | 390 (309–491) | 175 | 645 (556–747) | 522 (420–648) | |||
Female | 34,613 | 16 | 46 (28–75) | 42 (23–79) | 35 | 101 (72–141) | 89 (60–134) | 46 | 133 (100–177) | 133 (89–198) | |||
Age group | <0.001b | <0.001b | 0.001b | ||||||||||
15–24 | 6,542 | 0 | 0 | 0 | 4 | 61 (23–163) | 49 (19–127) | <0.001c | 4 | 61 (23–163) | 63 (18–226) | 0.007c | |
25–34 | 10,191 | 9 | 88 (46–170) | 109 (55–218) | 0.218c | 13 | 128 (74–220) | 142 (76–264) | 0.051c | 17 | 167 (104–268) | 203 (114–360) | 0.049c |
35–44 | 11,508 | 8 | 70 (35–139) | 69 (35–134) | 0.637c | 21 | 182 (119–280) | 185 (111–308) | 0.263c | 31 | 269 (190–383) | 287 (180–454) | 0.556c |
45–54 | 13,289 | 15 | 113 (68–187) | 123 (72–211) | 0.056c | 42 | 316 (233–427) | 344 (239–496) | 0.034c | 50 | 376 (285–496) | 423 (300–597) | 0.113c |
55–64 | 11,143 | 13 | 117 (68–201) | 130 (68–251) | 0.116c | 52 | 466 (356–612) | 505 (365–698) | <0.001c | 62 | 556 (434–713) | 618 (463–823) | <0.001c |
≥ 65 | 9,090 | 5 | 55 (23–132) | 55 (18–167) | 0.515c | 41 | 451 (332–612) | 446 (317–629) | <0.001c | 57 | 627 (484–812) | 689 (511–930) | <0.001c |
Area | 0.034 | 0.004 | 0.024 | ||||||||||
Urban | 18,656 | 27 | 145 (99–211) | 140 (86–228) | 0.008c | 75 | 402 (321–504) | 342 (252–463) | 0.008c | 90 | 482 (393–593) | 445 (327–604) | 0.020c |
Remote | 15,882 | 13 | 82 (48–141) | 76 (44–133) | 0.893c | 44 | 277 (206–372) | 247 (148–414) | 0.818c | 52 | 327 (250–429) | 309 (181–526) | 0.852c |
Rural | 27,225 | 10 | 37 (20–68) | 37 (15–93) | 0.032c | 54 | 198 (152–259) | 152 (108–215) | 0.003c | 79 | 290 (233–362) | 241 (182–572) | 0.027c |
Region | 0.129 | 0.159 | 0.297 | ||||||||||
North | 25,575 | 10 | 39 (21–73) | 44 (22–86) | 0.131c | 49 | 192 (145–253) | 168 (105–267) | 0.102c | 70 | 274 (217–346) | 262 (180–380) | 0.173c |
central | 13,525 | 14 | 104 (61–175) | 92 (48–176) | 0.044c | 42 | 311 (230–420) | 253 (152–423) | 0.067c | 49 | 362 (274–479) | 316 (181–552) | 0.939c |
South | 22,663 | 26 | 115 (78–168) | 106 (62–182) | 0.640c | 82 | 362 (292–449) | 289 (216–385) | 0.749c | 102 | 450 (371–546) | 380 (287–504) | 0.163c |
No: number; CI: confidence interval; N/A: Not available
a Weighted prevalence: estimated prevalence after missing data imputation, inverse probability weighting and post-stratification (see more in the Data collection and analysis section)
b p-value for trend, obtain by Wald test
c p-value for the difference between this age group/area/region with other groups combined, obtained with logit regression
Reference
- 1.Nguyen HV, Tiemersma EW, Nguyen HB, Cobelens FGJ, Finlay A, Glaziou P, et al. (2020) The second national tuberculosis prevalence survey in Vietnam. PLoS ONE 15(4): e0232142 10.1371/journal.pone.0232142 [DOI] [PMC free article] [PubMed] [Google Scholar]