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An event is serious (based on the ICH definition) when the patient outcome is:
* death
* life-threatening
* hospitalisation
* disability
* congenital anomaly
* other medically important event
A 74-year-old man exhibited lack of efficacy during treatment with metoprolol for ventricular tachycardia.
The man was admitted to hospital due to haemodynamically unstable new-onset ventricular tachycardia of 12 hours duration. Then, he self-administered oral metoprolol 200mg. However, the therapy was unsuccessful, and arrhythmia was electrically cardioverted with subsequent symptomatic bradycardia and hypotension. On the following day of hospital admission, a recurrence of ventricular tachycardia occurred. He received unspecified magnesium substitution and amiodarone, and his rhythm stabilised. On the sixth day of hospitalisation, PCR showed positive results for SARS-CoV-2. Thus, he received a single 500mg dose of azithromycin and a single 75mg dose of oseltamivir. On the seventeenth day, reverse PCR showed positive results for SARS-CoV-2.