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mTOR inhibition alters transcriptional machinery at Id2 promoter. ChIP assays performed in primary rat OPCs after 72 hr of differentiation ±15 nM rapamycin. (a) Representative PCR gels and (b) quantification of Id2 promoter bound to immunoprecipitated proteins (n = 3). Smad, Sip1, HDAC1, and HDAC2 were immunoprecipitated and Id2 promoter region was PCR amplified from bound chromatin. Input DNA was used as positive control. Values expressed as mean ± SEM. **p < .01
