Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E–Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

Abstract

PURPOSE

To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E–mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial (ClinicalTrials.gov identifier: NCT02928224; European Union Clinical Trials Register identifier: EudraCT2015-005805-35).

PATIENTS AND METHODS

Before initiation of the randomized portion of the BEACON Colorectal Cancer trial, 30 patients with BRAF V600E–mutant mCRC who had experienced treatment failure with one or two prior regimens were to be recruited to a safety lead-in of encorafenib 300 mg daily, binimetinib 45 mg twice daily, plus standard weekly cetuximab. The primary end point was safety, including the incidence of dose-limiting toxicities. Efficacy end points included overall response rate, progression-free survival, and overall survival.

RESULTS

Among the 30 treated patients, dose-limiting toxicities occurred in five patients and included serous retinopathy (n = 2), reversible decreased left ventricular ejection fraction (n = 1), and cetuximab-related infusion reactions (n = 2). The most common grade 3 or 4 adverse events were fatigue (13%), anemia (10%), increased creatine phosphokinase (10%), increased AST (10%), and urinary tract infections (10%). In 29 patients with BRAF V600E–mutant tumors (one patient had a non–BRAF V600E–mutant tumor and was not included in the efficacy analysis), the confirmed overall response rate was 48% (95% CI, 29.4% to 67.5%), median progression-free survival was 8.0 months (95% CI, 5.6 to 9.3 months), and median overall survival was 15.3 months (95% CI, 9.6 months to not reached), with median duration of follow-up of 18.2 months (range, 16.6 to 19.8 months).

CONCLUSION

In the safety lead-in, the safety and tolerability of the encorafenib, binimetinib, and cetuximab regimen is manageable and acceptable for initiation of the randomized portion of the study. The observed efficacy is promising compared with available therapies and, if confirmed in the randomized portion of the trial, could establish this regimen as a new standard of care for previously treated BRAF V600E–mutant mCRC.

INTRODUCTION

BRAF V600E mutation is found in approximately 8% to 15% of patients with metastatic colorectal cancer (mCRC) and is a marker of poor prognosis.^1-4 Because BRAF V600E and RAS mutations are nearly always mutually exclusive,⁵ patients with BRAF V600–mutant mCRC have typically been treated with standard-of-care regimens for RAS wild-type mCRC.^6-9 Standard first-line therapy, even with intensified regimens, produces poorer results in patients with BRAF V600E–mutant mCRC than in patients with wild-type disease,^10-12 and after standard first-line therapy, subsequent treatment provides limited benefits, with reported overall response rates (ORRs) of less than 10%, median progression-free survival (PFS) times of approximately 2 months, and median overall survival (OS) times ranging from 4 to 6 months.^2,13-19 Immunotherapies such as nivolumab and pembrolizumab are active in patients with microsatellite instability–high or mismatch repair–deficient solid tumors, including mCRC.^20,21 Although the rate of mismatch repair deficiency is higher in BRAF V600E–mutant CRC than in BRAF wild-type disease, recent prospective data and a pooled analysis of four clinical trials indicated that less than 20% of patients with BRAF V600E–mutant mCRC have microsatellite instability–high or mismatch repair–deficient tumors, thus limiting this option to a minority of patients.^19,22-24

Unlike in other tumor histologies with BRAF V600 mutations such as melanoma and non–small-cell lung cancer, where BRAF inhibition is clinically highly active,^25-36 BRAF inhibition in BRAF V600E–mutant mCRC produced only marginal clinical activity.^35,37-39 In vitro studies later demonstrated that in BRAF V600E–mutant colorectal cancer (CRC) cells, BRAF inhibition results in rapid feedback activation of epidermal growth factor receptor (EGFR), permitting sustained MAPK activation and continued cell proliferation; however, combined inhibition of BRAF and EGFR resulted in synergistic inhibition of tumor growth in BRAF V600E–mutant CRC xenograft models.^40,41 Subsequent clinical studies of EGFR-targeted monoclonal antibodies combined with BRAF inhibition using the BRAF inhibitors vemurafenib or dabrafenib confirmed that addition of an EGFR-targeted therapy can improve the activity of BRAF inhibition in BRAF V600E–mutant CRC.^42-44 In addition, preclinical studies indicated that profound inhibition of the MAPK pathway and greater antitumor activity could be achieved with the addition of a MEK inhibitor to BRAF inhibition, and this was also validated clinically.^41,45,46 Despite improvements in the activity of these regimens, to date, triplet combinations of BRAF inhibition with EGFR-targeted therapy and either a MEK inhibitor or irinotecan have demonstrated response rates of approximately 20%, in contrast to response rates of 60% to 70% for combined dual BRAF/MEK inhibition alone in melanoma and non–small-cell lung cancer.^{19,34,36,44,47}

The combination of encorafenib, a BRAF inhibitor, and binimetinib, a MEK inhibitor, has recently been approved in the United States and Europe for the first-line treatment of patients with BRAF V600–mutant melanoma.^48,49 Results from a recent phase II study in patients with BRAF V600E–mutant mCRC who received at least one prior regimen showed that the doublet of encorafenib plus cetuximab resulted in a confirmed ORR of 24%, a PFS of 4.2 months, and an OS of 9.3 months with a tolerable safety profile.⁵⁰ Relative to the standard of care and to other BRAF, MEK, and EGFR-inhibitor triplet combinations, the promising results with the encorafenib and cetuximab doublet supported the initiation of the phase III BEACON CRC study (ClinicalTrials.gov identifier: NCT02928224; European Union Clinical Trials Register identifier: EudraCT2015-005805-35).

BEACON CRC is an open-label, randomized, three-arm, phase III study evaluating the efficacy and safety of encorafenib plus cetuximab with or without binimetinib versus investigators’ choice of cetuximab combined with either irinotecan or fluorouracil, folinic acid, and irinotecan in patients with BRAF V600E–mutant mCRC whose disease has progressed after one or two prior regimens. At the time BEACON CRC was initiated, the triplet combination of binimetinib, encorafenib, and cetuximab had not been clinically evaluated. Therefore, a 30-patient safety lead-in (SLI) was conducted to determine the safety, tolerability, and preliminary efficacy of the triplet combination at the doses planned for the randomized portion of the trial. Here, we describe results of the BEACON CRC SLI. At the time of this analysis, the randomized portion of the trial was ongoing.

PATIENTS AND METHODS

Patients were required to be 18 years of age or older with histologically or cytologically confirmed mCRC, with the presence of BRAF V600E mutation in tumor tissue. Patients could enroll based on local determination of BRAF V600E mutation; however, confirmation by a central laboratory was required for all patients within 30 days of starting treatment. Patients must have had progression of disease on at least one but no more than two prior treatment regimens in the metastatic setting; have had evidence of measurable or evaluable, nonmeasurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1; have had an Eastern Cooperative Oncology Group performance status of 0 or 1; have been eligible to receive cetuximab per their local label; and have had adequate bone marrow, renal, hepatic, and cardiac function. Patients were excluded if they had previous treatment with any RAF or MEK inhibitor, cetuximab, panitumumab, or other EGFR inhibitor or had symptomatic brain metastasis or leptomeningeal disease. Additional details regarding inclusion and exclusion criteria are provided in the Data Supplement.

The SLI was performed at seven sites in four countries (two in Belgium, one in the Netherlands, two in Spain, and two in the United States). The study was approved by the ethics committee for each study site. All clinical work was conducted in compliance with current Good Clinical Practices as referenced in the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. All patients enrolled in the study provided written, informed consent before their participation.

Study Procedures

The first nine patients were enrolled in the SLI on a rolling basis. These patients received encorafenib 300 mg every day plus binimetinib 45 mg twice a day plus cetuximab 400 mg/m² followed by 250 mg/m² intravenously weekly in 28-day cycles. The cohort was to be expanded to a total of 30 patients in the dose-expansion cohort based on assessments of the safety data in the first nine patients by the data monitoring committee.

Outcome Measures

Safety was evaluated by ongoing monitoring of adverse events, clinical laboratory tests, vital signs, physical examinations, ophthalmic examinations, dermatologic examinations, ECGs, and echocardiography or multigated acquisition scans. Tumors were assessed using radiologic imaging (eg, computed tomography, magnetic resonance imaging, x-ray, whole-body bone scans), with tumor response determined locally by the investigator and by blinded independent central review according to RECIST, version 1.1. Tumor assessments were performed every 6 weeks for the first 24 weeks, then every 12 weeks until disease progression, withdrawal of consent, or initiation of subsequent anticancer therapy.

Statistical Methods

Study population.

All patients who received at least one dose of study drug were included in the safety analyses (N = 30). For efficacy analyses, all patients with a BRAF V600E mutation (confirmed by local assessment, central assessment, or both) who received at least one dose of study drug were included.

End points.

The primary end point of the SLI was the assessment of safety and tolerability, which included dose-limiting toxicities (DLTs; defined as any adverse event [AE] or abnormal laboratory values assessed as unrelated to disease, disease progression, intercurrent illness, or concomitant medications or therapies occurring within the first 28 days of treatment that met criteria that were established before the start of the study; Data Supplement); the incidence and severity of AEs and changes in clinical laboratory parameters, vital signs, ECGs, echocardiography or multigated acquisition scans, and ophthalmic examinations; and the incidence of dose interruptions, dose modifications, and discontinuations.

Efficacy end points included confirmed ORR (per RECIST version 1.1), duration of response (DOR), PFS (per RECIST version 1.1), time to response, and OS. Radiographic assessment of tumor response and progression was determined locally by the investigator. Blinded central review of radiographically determined tumor response and progression was also conducted retrospectively and reported. Pharmacokinetic end points were also evaluated and will be presented elsewhere.

Statistical analysis.

Descriptive statistics were used to summarize pretreatment characteristics and to evaluate DLTs, frequency of AEs, and best overall response. PFS was defined as the time from first dose of study drug to the earliest documented date of disease progression, per RECIST version 1.1, or death from any cause. OS was defined as the time from first dose of study drug to death from any cause. The survival status of all patients was assessed as of the cutoff date based on ongoing survival follow-up and public records where permitted. Data for patients who did not die by the data cutoff date were censored for OS at their last contact date. DOR was defined as time from first radiographic evidence of response to the earliest documented disease progression or death. Time to response was defined as time from first dose of study treatment to first radiographic evidence of response. The Kaplan-Meier method was used to estimate PFS and OS rates. This was also used to assess DOR.

RESULTS

Thirty patients were enrolled in the SLI of BEACON CRC between November 1, 2016, and April 24, 2017; as of September 2, 2018, treatment remained ongoing for six patients (20%; Fig 1). A total of 24 patients (80%) discontinued from the study, with the primary reason for study discontinuation being disease progression (n = 21; 70%).

FIG 1.

Patient disposition. (*) One treated patient had a non-V600 BRAF mutation (BRAF G466V). (†) Includes two patients with changes in condition or development of an intercurrent illness. (‡) Dose interruption for more than 28 consecutive days. (§) As of the data cutoff date of September 2, 2018. AE, adverse event.

Patient Disposition and Characteristics

Patient demographic and baseline tumor characteristics are listed in Table 1. Patients were characteristic of a population of patients with BRAF V600E–mutant mCRC, with predominantly right-sided disease and high frequency of nodal and peritoneal metastasis, although the liver was the most frequent site of metastasis. One patient had a non-V600 mutation of BRAF (G466V) and was included in the safety analysis but excluded from the efficacy analysis.

TABLE 1.

Baseline Patient and Tumor Characteristics (safety population)

Safety

DLTs.

DLTs were reported in five of 30 patients and included two patients with cetuximab-related drug hypersensitivity (grade 2 and grade 3; both patients remained in the study on binimetinib and encorafenib), two patients with grade 2 serous retinopathy (both patients remained in the study after an interruption of binimetinib dosing), and one patient with decreased left ventricular ejection fraction (grade 2) that resolved with the interruption of binimetinib dosing (the patient continued in the study on a reduced dose of binimetinib).

AEs.

Two patients (6.7%) experienced grade 1 toxicities; seven (23.3%) experienced grade 2 toxicities; 16 (53.3%) experienced grade 3 toxicities; and five (16.7%) experienced grade 4 toxicities. No grade 5 toxicities were reported. The most frequently reported treatment-emergent AEs (any grade) included diarrhea (77%), dermatitis acneiform (67%), fatigue (63%), and nausea (63%). The most frequently reported grade 3 or 4 treatment-emergent AEs included fatigue (13%; all grade 3), anemia (10%; two grade 3 and one grade 4), increased AST (10%; one grade 3 and two grade 4), increased creatine phosphokinase (10%; all grade 3), and urinary tract infections (10%; all grade 3; Tables 2 and 3).

TABLE 2.

Adverse Events, Regardless of Causality, Reported in Five or More Patients (safety population)

TABLE 3.

Grade 3 or 4 Adverse Events, Regardless of Causality, Reported in Two or More Patients (safety population)

Drug discontinuations as a result of AEs.

A total of six patients (20%) had at least one study drug discontinued as a result of AEs. Among these, one patient (3.3%) discontinued all three drugs as a result of grade 2 fatigue; two patients (6.7%) discontinued binimetinib alone as a result of increased blood creatinine (n = 1) and retinal detachment (n = 1); two patients (6.7%) discontinued cetuximab alone as a result of an allergic reaction; and one patient (3.3%) discontinued both encorafenib and binimetinib as a result of increased blood bilirubin. At the time of the increased blood bilirubin, there was radiographic evidence of extrinsic obstruction of the gallbladder. The patient received a dose of cetuximab 2 weeks after discontinuation of encorafenib and binimetinib and then discontinued study treatment completely 2 weeks later as a result of clinical progression. There were five on-treatment deaths (17%), all a result of disease progression.

Efficacy

Efficacy was assessed in the 29 patients with BRAF V600E mutation–containing tumors. The median time on study drug was 7.9 months (range, 1.0 to 21.4 months), and median follow-up time for survival was 18.2 months (range, 16.6 to 19.8 months).

Overall response.

Confirmed best overall responses are listed in Table 4. The ORR per local assessment was 48% (95% CI, 29.4% to 67.5%). Fourteen patients had a confirmed response; three patients (10%) had complete responses, and 11 patients (38%) had partial responses. The ORR, as determined by retrospective central assessment, was 41% (95% CI, 23.5% to 61.1%), with two complete responses (7%) and 10 partial responses (34%). Changes in tumor measurements from baseline are presented in Figure 2.

TABLE 4.

Best Overall Response to Treatment

FIG 2.

Best percent change from baseline in sum of tumor diameters based on (A) local assessment and (B) central assessment. One patient was without postbaseline sum of diameters (not presented). Colors represent best response (confirmed) of partial response (PR) or complete response (CR). The category other represents stable disease (SD) or not evaluable (NE). Patients with CR, defined as the disappearance of all target lesions, could have pathologic lymph node metastases present; target or nontarget lymph node metastases must have had reduction in short axis to less than 10 mm. The other category includes stable disease or patient not evaluable.

Among the 17 patients treated with one prior therapy, ORRs per local and central assessment were 59% (95% CI, 32.9% to 81.6%) and 53% (95% CI, 27.8% to 77.0%), respectively. Among the 12 patients treated with two prior therapies, the local ORR was 33% (95% CI, 9.9% to 65.1%), with corresponding rates from central assessment of 25% (95% CI, 5.5% to 57.2%).

Time to response.

Per local assessment, 78.6% of responding patients achieved a response within 2 months, 92.9% within 4 months, and all patients within 6 months of treatment initiation. On the basis of central assessment, 75.0% of responding patients achieved response within 2 months, 91.7% within 4 months, and all patients within 12 months of treatment initiation.

DOR.

Among responders (n = 14), the median DOR per local assessment was 5.5 months (95% CI, 4.1 months to not reached [NR]); 85.7% of patients achieved a DOR of 3 months, 42.9% achieved a DOR of 6 months, and 25.7% achieved a DOR of 15 months. Median DOR among the 12 responders confirmed by central assessment was 8.1 months (95% CI, 2.8 months to NR); 73% of patients achieved a DOR of 6 months or longer (Data Supplement).

PFS and OS.

Median PFS was 8.0 months (95% CI, 5.6 to 9.3 months; Fig 3A) per local assessment and 5.5 months (95% CI, 4.2 to 9.3 months) per central assessment. Median PFS (by local assessment) by number of prior regimens was similar: 8.0 months (95% CI, 5.6 to 9.7 months) for patients who received one prior regimen compared with 7.7 months (95% CI, 4.1 to 10.8 months) for patients who received two prior regimens. The median OS time was 15.3 months (95% CI, 9.6 months to NR; Fig 3B), with median duration of follow-up of 18.2 months (range, 16.6 to 19.8 months). The 12-month OS rate was 62% (95% CI, 42.1% to 76.9%).

FIG 3.

Kaplan-Meier plots of (A) progression-free survival (PFS; local assessment) and (B) overall survival (OS).

NR, not reached.

DISCUSSION

On the basis of the safety and efficacy results of the SLI phase of the BEACON CRC study, the randomized phase of the study was initiated and is ongoing. The safety profile of the triplet combination regimen of binimetinib, encorafenib, and cetuximab was similar to that previously reported for the individual agents and included predominantly GI and skin toxicities. Higher grade (grade 3 or 4) skin toxicities were rare and were less common than the 12% rate of grade 3 or 4 rash reported for cetuximab monotherapy,⁴⁸ suggesting that BRAF inhibition may ameliorate this cetuximab-related AE. Although the overall rates of grade 3 and grade 4 toxicity were 53.3% and 16.7%, respectively, there was no single predominant toxicity driving these rates, with only the event of fatigue (13%) reported at a rate higher than 10%. The regimen appeared to be well tolerated and the safety profile manageable; a few patients (six patients [20%]) required dose discontinuation of at least one of the study drugs as a result of an AE and only one patient discontinued treatment with all three agents as a result of a drug-related AE. Patients requiring dose discontinuation included two patients who required discontinuation of cetuximab as a result of infusion reactions, a rate consistent with prior reports for cetuximab infusion reactions.⁵¹ The addition of the MEK inhibitor binimetinib did result in some patients experiencing MEK inhibitor class–related AEs including serous retinopathy, increased creatine phosphokinase, and decreases in left ventricular ejection fraction. Serous retinopathy (also referred to as retinal pigment epithelial detachment) is a known MEK inhibitor–associated toxicity and was observed as a grade 2 DLT in two patients. It was documented to reverse in all patients who underwent repeat ophthalmologic examination; in one patient, ophthalmologic examination was not repeated but the patient continued on study treatment without loss of visual acuity. Serous retinopathy is most often asymptomatic, and reported rates depend on the frequency of monitoring.²⁹ Symptomatic serous retinopathy is generally reversible and manageable with dose interruption, with or without subsequent dose reduction.⁵² Increased creatine phosphokinase was also observed (37%) but is rarely associated with significant myopathy, and it led to dose modification in only one patient. Clinically significant MEK inhibitor–associated left ventricular dysfunction is uncommon and is generally reversible with interruption and dose modification. Grade 2 left ventricular dysfunction was reported as a DLT in one patient, was reversed with binimetinib interruption, and did not lead to treatment discontinuation.

Benchmarked against both prior standards of care for RAS wild-type metastatic CRC as well as more recent experience with other BRAF inhibitor combinations, including triplet combinations with cetuximab and either irinotecan or the MEK inhibitor trametinib,^19,44 the efficacy findings from the SLI are promising. The confirmed ORR was 48%, with 43% of responses lasting for more than 6 months. The median PFS time was 8 months and median OS time was 15.3 months, with a median duration of follow-up of 18.2 months. Results by central review were, in general, consistent with local review findings. By comparison, expected outcomes for historical second- and third-line standards of care, similar to the control arm of the randomized portion of the trial, included an ORR of less than 10%, median PFS of 2 to 3 months, and median OS of 4 to 6 months.^2,13-19 Similarly, other triplet therapy regimens incorporating a BRAF inhibitor and an EGFR-targeted monoclonal antibody (dabrafenib, trametinib, and panitumumab and vemurafenib, irinotecan, and cetuximab) have shown improved but limited efficacy, with ORRs of 16% to 21%, median PFS of approximately 4.2 to 5.6 months, and median OS of 9.1 to 9.6 months.^19,39 Although the mechanisms underlying the outcomes associated with encorafenib and binimetinib combined with cetuximab remain to be fully characterized, preclinical data suggest that encorafenib has target binding characteristics that differ from both vemurafenib and dabrafenib, with a prolonged target dissociation half-life and higher potency.⁵³ Clinically, although never compared head-to-head with other BRAF/MEK inhibitor combinations, in the COLUMBUS trial (ClinicalTrials.gov identifier: NCT01909453) in patients with advance BRAF V600K or V600E melanoma,^29,36 the combination of binimetinib and encorafenib produced new benchmarks for efficacy as measured by PFS (median, 14.9 months; 95% CI, 11.0 to 18.5 months) and OS (median, 33.6 months; 95% CI, 24.4 to 39.2 months). Vemurafenib monotherapy, the control arm in the COLUMBUS study, performed almost identically to its activity in pivotal trials of other BRAF/MEK inhibitor combinations. In addition, the COLUMBUS trial did include a head-to-head comparison of encorafenib monotherapy at 300 mg daily and vemurafenib monotherapy and demonstrated improved PFS (hazard ratio, 0.68; 95% CI, 0.52 to 0.88) and OS (hazard ratio, 0.76; 95% CI, 0.58 to 0.98) for encorafenib relative to vemurafenib in patients with BRAF V600E– or BRAF V600K–mutated advanced melanoma.³⁶ Thus, the data suggest that the differences between encorafenib and other BRAF inhibitors in terms of target binding may underlie the observed differences clinically, including efficacy in BRAF V600E–mutated CRC, which in terms of the ability to modulate the MAPK pathway is inherently less sensitive to BRAF inhibition than melanoma.^40,41

The randomized portion of the BEACON CRC study is ongoing, and if results approximate those from the SLI, the combination of binimetinib, encorafenib, and cetuximab may become a new standard of care for patients with previously treated BRAF V600E–mutated CRC. To maximize the potential for benefit to patients, results warrant additional investigation of this regimen in the first-line and potentially the adjuvant settings. A trial to investigate the regimen in the first-line setting (ANCHOR-CRC [Encorafenib, Binimetinib, and Cetuximab in Subjects With Previously Untreated BRAF-Mutant Colorectal Cancer]; ClinicalTrials.gov identifier: NCT03693170) was recently initiated.

AUTHOR CONTRIBUTIONS

Conception and design: Eric Van Cutsem, Axel Grothey, Pieter-Jan Cuyle, Elena Elez, Harpreet Wasan, Fortunato Ciardiello, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan H.M. Schellens, Scott Kopetz, Josep Tabernero

Administrative support: Harpreet Wasan

Provision of study materials or patients: Eric Van Cutsem, Sanne Huijberts, Pieter-Jan Cuyle, Elena Elez, Harpreet Wasan, Fortunato Ciardiello, Ashwin Gollerkeri, Josep Tabernero

Collection and assembly of data: Eric Van Cutsem, Sanne Huijberts, Axel Grothey, Rona Yaeger, Elena Elez, Marwan Fakih, Clara Montagut, Marc Peeters, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan H.M. Schellens, Scott Kopetz, Josep Tabernero

Data analysis and interpretation: Eric Van Cutsem, Sanne Huijberts, Axel Grothey, Rona Yaeger, Pieter-Jan Cuyle, Elena Elez, Marwan Fakih, Marc Peeters, Takayuki Yoshino, Harpreet Wasan, Jayesh Desai, Fortunato Ciardiello, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan H.M. Schellens, Scott Kopetz, Josep Tabernero

Manuscript writing: All authors

Final approval of manuscript: All authors

Accountable for all aspects of the work: All authors

AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E–Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc.

Eric Van Cutsem

Consulting or Advisory Role: Bayer, Eli Lilly, Roche, Servier, Bristol-Myers Squibb, Celgene, Merck Sharp & Dohme, Merck KGaA, Novartis, AstraZeneca

Research Funding: Amgen (Inst), Bayer (Inst), Boehringer Ingelheim (Inst), Eli Lilly (Inst), Novartis (Inst), Roche (Inst), Celgene (Inst), Ipsen (Inst), Merck (Inst), Merck KGaA (Inst), Servier (Inst), Bristol-Myers Squibb (Inst)

Axel Grothey

Honoraria: Elsevier, Aptitude Health

Consulting or Advisory Role: Genentech (Inst), Bayer (Inst), Bristol-Myers Squibb (Inst), Eli Lilly (Inst), Boston Biomedical (Inst), Amgen (Inst), Array BioPharma (Inst), Guardant Health (Inst), Daiichi Sankyo (Inst)

Research Funding: Genentech (Inst), Bayer (Inst), Pfizer (Inst), Eisai (Inst), Eli Lilly (Inst), Boston Biomedical (Inst), Daiichi Sankyo (Inst), Array BioPharma (Inst)

Travel, Accommodations, Expenses: Genentech, Bayer, Bristol-Myers Squibb, Boston Biomedical, Amgen, Boehringer Ingelheim, Merck Sharp & Dohme

Rona Yaeger

Research Funding: Array BioPharma, GlaxoSmithKline, Novartis

Travel, Accommodations, Expenses: Array BioPharma

Pieter-Jan Cuyle

Consulting or Advisory Role: Eli Lilly, Genentech, Amgen, Novartis, Merck

Elena Elez

Consulting or Advisory Role: Amgen, Roche, Merck Serono, Sanofi, Servier, Bayer

Research Funding: Merck Serono

Travel, Accommodations, Expenses: Roche, Merck Serono, Sanofi, Amgen

Marwan Fakih

Consulting or Advisory Role: Amgen, Array BioPharma, Genentech

Speakers' Bureau: Amgen, Taiho Pharmaceutical

Research Funding: Novartis (Inst), Amgen (Inst), AstraZeneca (Inst)

Clara Montagut

Consulting or Advisory Role: Amgen, Merck Serono, Sanofi, Guardant Health

Speakers' Bureau: Sysmex

Research Funding: Symphogen

Patents, Royalties, Other Intellectual Property: Patent licensed by Biocartis (Inst)

Marc Peeters

Honoraria: Amgen, Bayer, Celgene, Merck Serono, Roche, Sanofi, Servier, Sirtex Medical

Consulting or Advisory Role: Amgen, Bayer, IQVIA, Ipsen, Remedus, Sanofi, Servier, Sirtex Medical, Terumo

Speakers' Bureau: Amgen, Bayer, Celgene, Merck Serono, Roche, Sanofi, Servier, Sirtex Medical

Research Funding: Amgen, Bayer, Ipsen, Novartis, Roche

Takayuki Yoshino

Research Funding: Chugai Pharma (Inst), Sanofi (Inst), Sumitomo Dainippon (Inst), GlaxoSmithKline (Inst)

Harpreet Wasan

Honoraria: Merck KGaA, Celgene, Sirtex Medical, Servier, Array BioPharma, Shire, Genentech, ERYTECH Pharma

Consulting or Advisory Role: Roche Pharma AG, SITEX Medical, ERYTECH Pharma, Shire, Incyte

Speakers' Bureau: Sirtex Medical, Celgene, Merck KGaA, Servier

Research Funding: Sirtex Medical (Inst), Merck KGaA (Inst), Pfizer (Inst), Merck Sharp & Dohme (Inst)

Jayesh Desai

Consulting or Advisory Role: Bionomics, Eli Lilly, Eisai, BeiGene, Ignyta (Inst)

Research Funding: Roche (Inst), GlaxoSmithKline (Inst), Novartis (Inst), Bionomics (Inst), MedImmune (Inst), BeiGene (Inst), Eli Lilly (Inst), Bristol-Myers Squibb (Inst)

Fortunato Ciardiello

Consulting or Advisory Role: Genentech, Merck KGaA, Bayer, Amgen, Pfizer

Research Funding: Merck KGaA (Inst), Genentech (Inst), Servier (Inst), Symphogen (Inst), Amgen (Inst), Bayer (Inst), Merck Sharp & Dohme (Inst), Bristol-Myers Squibb (Inst), Ipsen (Inst)

Ashwin Gollerkeri

Employment: Array BioPharma, Alnylam (I), Bluebird Bio (I)

Stock and Other Ownership Interests: Array BioPharma, Alnylam (I)

Honoraria: Bluebird Bio (I)

Patents, Royalties, Other Intellectual Property: Receives royalties from Yale University on an antibody used in nephrology basic research (I)

Janna Christy-Bittel

Employment: Array Biopharma

Stock and Other Ownership Interests: Array Biopharma, Gilead Sciences

Kati Maharry

Employment: Array BioPharma

Stock and Other Ownership Interests: Array BioPharma

Travel, Accommodations, Expenses: Array BioPharma

Victor Sandor

Employment: Array BioPharma

Leadership: Array BioPharma

Stock and Other Ownership Interests: Array BioPharma

Jan H.M. Schellens

Employment: Modra Pharmaceuticals

Stock and Other Ownership Interests: Modra Pharmaceuticals

Honoraria: Debiopharm Group

Consulting or Advisory Role: Debiopharm Group

Research Funding: Dutch Cancer Society

Patents, Royalties, Other Intellectual Property: Patent on oral taxanes

Scott Kopetz

Stock and Other Ownership Interests: MolecularMatch, Navire

Consulting or Advisory Role: Roche, Genentech, EMD Serono, Merck, Karyopharm Therapeutics, Amal Therapeutics, Navire Pharma, Symphogen, Holy Stone, Biocartis, Amal Therapeutics, Amgen, Novartis, Eli Lilly, Boehringer Ingelheim

Research Funding: Amgen (Inst), Sanofi (Inst), Biocartis (Inst), Guardant Health (Inst), Array BioPharma (Inst), Genentech (Inst), EMD Serono (Inst), MedImmune (Inst), Novartis (Inst)

Josep Tabernero

Consulting or Advisory Role: Bayer, Boehringer Ingelheim, Eli Lilly, MSD, Merck Serono, Novartis, Sanofi, Taiho Pharmaceutical, Merrimack, Peptomyc, Rafael Pharmaceuticals, Symphogen, Chugai Pharma, Ipsen, Merus, Pfizer, Seattle Genetics, Array BioPharma, AstraZeneca, BeiGene, Genentech, Genmab, Halozyme, Imugene Limited, Inflection Biosciences Limited, Kura, Menarini, Molecular Partners, Pharmacyclics, ProteoDesign SL, Roche, Seattle Genetics, Servier, VCN Biosciences, Biocartis, Foundation Medicine, HalioDX SAS, Roche Diagnostics

No other potential conflicts of interest were reported.