Comparison of mutational load, chromosome integrity number, somatic mutations and copy number variation between patients with poor prognosis and patients with good prognosis [Panel A]. Odds Ratio analysis [Panel B] of somatic mutations (Panel A) and copy-number variation (Panel B) according to prognosis: an OR<1 indicates a higher chance to be associated with good prognosis; an OR>1 indicates a higher chance to be associated with poor prognosis. CIN, chromosome integrity number; CNV, copy number variation; OR, odds Ratio; CI, confidence interval; SM, somatic mutation; CNV, copy number variation.