Table 1.

Clinical and Laboratory Characteristics of Women with Obstetric Antiphospholipid Syndrome (Obs-APS) in APS ACTION registry with/without Subsequent Non-gravid Thrombosis.

Variables, n (%)	Obstetric APS only (n=52)	Obstetric APS followed by Thrombosis (n=47)	p value
Demographics
Age of first pregnancy morbidity	28.9 ± 6.77	26.25 ± 5.52	0.03
Associated Autoimmune Disease
No other autoimmune disease	28 (53.8%)	29 (61.7%)	0.21
SLE	12 (23.0%)	8 (17.0%)	0.22
Lupus-like disease (3 American College of Rheumatology criteria for lupus)	6 (11.5%)	2 (4.2%)	0.09
Other	6 (11.5%)	8 (17.0%)	0.43
Vascular Events
Venous Thrombosis	NA	25 (53.1%)	NA
Arterial Thrombosis	NA	17 (36.1%)	NA
Venous and Arterial Thrombosis	NA	5 (10.6%)	NA
Cardiovascular Risk Factors at registry entry
Hypertension on medication	11 (21.1%)	20 (42.5)	0.01
Diabetes on medication	1 (1.9%)	3 (6.3%)	0.13
Hyperlipidemia on medication	3 (5.7%)	8 (17.0%)	0.03
Obesity (BMI > 30)	6 (11.5%)	11 (23.4%)	0.06
Smoking (ever)	9 (17.3%)	18 (38.2%)	0.009
First Pregnancy Morbidity
Fetal Loss	34 (65.3%)	30 (63.8%)	0.43
Premature Birth < 34 week	14 (26.9%)	12 (25.5%)	0.43
≥ Three (pre)-embryonic loss	4 (7.6%)	5 (10.6%)	0.30
Non-Criteria Manifestations
Superficial Vein Thrombosis	1 (1.9%)	6 (12.7%)	0.01
Transient Ischemic Attack	4 (7.6%)	7 (14.8%)	0.12
Livedo	6 (11.5%)	11 (23.4%)	0.06
Thrombocytopenia	12 (23.0%)	10 (21.2%)	0.41
Hemolytic Anemia	3 (5.7%)	4 (8.5%)	0.29
Heart Valve Disease	1 (1.9%)	6 (12.7%)	0.01
Skin Ulcer	0	4 (8.5%)	NA
aPL-Nephropathy	2 (3.8%)	0	NA
Laboratory parameters
Lupus Anticoagulant (alone or with other autoantibodies)	35 (67.3%)	42 (89.3%)	0.004
Triple Positivity	17 (32.6%)	13 (27.6%)	0.29