. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Ophthalmology. 2020 Feb 7;127(8):1105–1112. doi: 10.1016/j.ophtha.2020.01.052

Table 2. Comorbidities and use of targeted oxygen saturations of study cohort displayed by peak disease severity.

Infants who developed treatment-requiring (TR) disease with aggressive posterior retinopathy of prematurity (AP-ROP) had higher rates of chronic lung disease than other infants with ROP.

Peak severity	n (eyes)	RBC transfusion	Chronic lung disease	Sepsis	IVH	NEC	PVL^†
No ROP	841	50%^***	17%^***	19%^***	18%^***	7.0%^***	3.1%
Mild ROP	584	75%^**	34%^***	31%^***	24%^*	21%^**	3.5%
Type 2 or Pre-Plus	282	91%	58%^**	36%^*	33%	21%^*	9%
TR without AP-ROP	120	93%	58%^*	51%	41%	29%	7%
TR with AP-ROP	62	93%	80%	59%	40%	36%	7%

Statistically significant difference compared to TR with AP-ROP category, p<0.05

^**

Statistically significant difference compared to TR with AP-ROP, p<0.01

^***

Statistically significant difference compared to TR with AP-ROP, p<0.001

^†

Chi-squared approximation may be invalid due to few subjects with PVL overall, including limited number within TR with AP-ROP group

ROP= retinopathy of prematurity; TR= treatment-requiring; AP-ROP= aggressive posterior retinopathy of prematurity; RBC= red blood cell; IVH= intraventricular hemorrhage; NEC= necrotizing enterocolitis; PVL= periventricular leukomalacia