Abstract
India observed a significant reduction in malaria cases in the previous year, reaffirming our trust and efficiency of the existing tools to achieve malaria elimination. On 25 April, 2019, countries around the world marked World Malaria Day under the theme “Zero malaria starts with me”. This provides an opportunity to rejoice the success and re-evaluate ongoing challenges in the fight against this preventable and treatable parasitic disease. We highlight the potential gaps in the malaria elimination program, and underscore potential solutions and strategies to implement, improve and intensify the success of the national goal of malaria elimination by 2030.
Keyword: Diagnosis, Epidemiology, Vector-borne disease
Contributors: All authors have contributed, drafted and approved the manuscript.
Funding: None
Competing interests: None stated.
References
- 1.Sharma VP. Re-emergence of malaria in India. Ind J Med Res. 1996;103:26–45. [PubMed] [Google Scholar]
- 2.Guerin PJ, Dhorda M, Ganguly NK, Sibley CH. Malaria control in India: A national perspective in a regional and global fight to eliminate malaria. J Vector Borne Dis. 2019;56:41–5. doi: 10.4103/0972-9062.257773. [DOI] [PubMed] [Google Scholar]
- 3.World Health Organization. World Malaria Report 2019. Available from: https://www.who.int/publications-detail/world-malaria-report—2019. Accessed December 7, 2019.
- 4.National Vector Borne Disease Control Programme (NVBDCP). Malaria. Available from: https://nvbdcp.gov.in/index1.php?lang=1&level=1&sublinkid=5784&lid=3689. Accessed October 8, 2019.
- 5.Dhingra N, Jha P, Sharma VP, Cohen AA, Jotkar RM, Rodriguez PS, Million Death Study Collaborators et al. Adult and child malaria mortality in India: A nationally representative mortality survey. Lancet. 2010;376:1768–74. doi: 10.1016/S0140-6736(10)60831-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Sharma RK, Thakor HG, Saha KB, Sonal GS, Dhariwal AC, Singh N. Malaria situation in India with special reference to tribal areas. Indian J Med Res. 2015;141:537–41. doi: 10.4103/0971-5916.159510. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Nema S, Verma AK, Bharti PK. Strengthening diagnosis is key to eliminating malaria in India. Lancet Infect Dis. 2019;19:1277–8. doi: 10.1016/S1473-3099(19)30544-4. [DOI] [PubMed] [Google Scholar]
- 8.Okell LC, Ghani AC, Lyons E, Drakeley CJ. Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis. J Infect Dis. 2009;200:1509–17. doi: 10.1086/644781. [DOI] [PubMed] [Google Scholar]
- 9.Ahmad A, Verma AK, Krishna S, Sharma A, Singh N, Bharti PK. Plasmodium falciparum glutamate dehydro-genase is genetically conserved across eight malaria endemic states of India: Exploring new avenues of malaria elimination. PloS One. 2019;14:e0218210. doi: 10.1371/journal.pone.0218210. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Singh MP, Chand SK, Saha KB, Singh N, Dhiman RC, Sabin LL. Unlicensed medical practitioners in tribal dominated rural areas of central India: Bottleneck in malaria elimination. Malaria J. 2020;19:18. doi: 10.1186/s12936-020-3109-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Singh J, Purohit B, Desai A, Savardekar L, Shanbag P, Kshirsagar N. Clinical manifestations, treatment, and outcome of hospitalized patients with Plasmodium vivax malaria in two Indian states: a retrospective study. Malar Res Treat. 2013;2013:341862. doi: 10.1155/2013/341862. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Douglas NM, Anstey NM, Buffet PA, Poespoprodjo JR, Yeo TW, White NJ, Price RN. The anaemia of Plasmodium vivax malaria. Malaria J. 2012;11:135. doi: 10.1186/1475-2875-11-135. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Medicines for Malaria Venture. Children and malaria: treating and protecting the most vulnerable. Available from: https://www.mmv.org/newsroom/publications/children-and-malaria-treating-and-protecting-most-vulnerable. Accessed December 8, 2019.
- 14.Kumar A, Valecha N, Jain T, Dash AP. Burden of malaria in India: Retrospective and prospective view. Am J Trop Med Hyg. 2007;77:69–78. doi: 10.4269/ajtmh.2007.77.69. [DOI] [PubMed] [Google Scholar]
- 15.Kitojo C, Gutman JR, Chacky F, Kigadye E, Mkude S, Mandike R, et al. Estimating malaria burden among pregnant women using data from antenatal care centres in Tanzania: a population-based study. Lancet Glob Hlth. 2019;7:e1695–705. doi: 10.1016/S2214-109X(19)30405-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Pereira MA, Clausen TM, Pehrson C, Mao Y, Resende M, Daugaard M, et al. Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1. PLoS Pathog. 2016;12:e1005831. doi: 10.1371/journal.ppat.1005831. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Zhou SS, Zhang SS, Zhang L, Rietveld AE, Ramsay AR, Zachariah R, et al. China’s 1-3-7 surveillance and response strategy for malaria elimination: Is case reporting, investigation and foci response happening according to plan? Infect Dis Poverty. 2015;4:55. doi: 10.1186/s40249-015-0089-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Sitohang V, Sariwati E, Fajariyani SB, Hwang D, Kurnia B, Hapsari RK, et al. Malaria elimination in Indonesia: Halfway there. Lancet Global Hlth. 2018;6:e604–6. doi: 10.1016/S2214-109X(18)30198-0. [DOI] [PubMed] [Google Scholar]
- 19.Lal AA, Rajvanshi H, Jayswar H, Das A, Bharti PK. Malaria elimination: Using past and present experience to make malaria-free India by 2030. J Vector Borne Dis. 2019;56:60–5. doi: 10.4103/0972-9062.257777. [DOI] [PubMed] [Google Scholar]
- 20.Hassanpour G, Mohebali M, Zeraati H, Raeisi A, Keshavarz H. Asymptomatic malaria and its challenges in the malaria elimination program in Iran: A systematic review. J Arthropod Borne Dis. 2017;11:172–4. [PMC free article] [PubMed] [Google Scholar]
- 21.Cheaveau J, Mogollon DC, Mohon MA, Golassa L, Yewhalaw D, Pillai DR. Asymptomatic malaria in the clinical and public health context. Expert Rev Anti-infect Ther. 2019;17:997–1010. doi: 10.1080/14787210.2019.1693259. [DOI] [PubMed] [Google Scholar]
- 22.Das S, Saha B, Hati AK, Roy S. Evidence of artemisinin-resistant Plasmodium falciparum malaria in eastern India. New Engl J Med. 2018;379:1962–4. doi: 10.1056/NEJMc1713777. [DOI] [PubMed] [Google Scholar]
- 23.van der Pluijm RW, Tripura R, Hoglund RM, Phyo AP, Lek D, Ul Islam A, et al. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial. Lancet. 2020;395:1345–60. doi: 10.1016/S0140-6736(20)30552-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Takeuchi R, Lawpoolsri S, Imwong M, Kobayashi J, Kaewkungwal J, Pukrittayakamee S, et al. Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border. Malaria J. 2010;9:308. doi: 10.1186/1475-2875-9-308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25.Gai PP, Van Loon W, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, et al. Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India. Malaria J. 2019;18:328. doi: 10.1186/s12936-019-2966-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26.Commons RJ, Simpson JA, Thriemer K, Hossain MS, Douglas NM, Humphreys GS, et al. Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis. Lancet Infect Dis. 2019;19:91–101. doi: 10.1016/S1473-3099(18)30596-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Eisele TP, Larsen D, Steketee RW. Protective efficacy of interventions for preventing malaria mortality in children in Plasmodium falciparum endemic areas. Int J Epidemiol. 2010;39(suppl_1):i88–101. doi: 10.1093/ije/dyq026. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Walldorf JA, Cohee LM, Coalson JE, Bauleni A, Nkanaunena K, Kapito-Tembo A, et al. School-age children are a reservoir of malaria infection in Malawi. PloS One. 2015;10:e0134061. doi: 10.1371/journal.pone.0134061. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29.Mishra AK, Bharti PK, Kareemi TI, Chand SK, Tidgam AS, Sharma RK, et al. Field evaluation of zero vector durable lining to assess its efficacy against malaria vectors and malaria transmission in tribal areas of the Balaghat district of central India. Trans Royal Soc Trop Med Hyg. 2019;113:623–31. doi: 10.1093/trstmh/trz046. [DOI] [PubMed] [Google Scholar]
- 30.Lancet T. Vaccines: A step change in malaria prevention? Lancet. 2015;385:1591–3. doi: 10.1016/S0140-6736(15)60774-7. [DOI] [PubMed] [Google Scholar]
- 31.Ghosh SK, Rahi M. Malaria elimination in India—the way forward. J Vector Borne Dis. 2019;56:32–40. doi: 10.4103/0972-9062.257771. [DOI] [PubMed] [Google Scholar]
- 32.Doolan DL, Hoffman SL. DNA-based vaccines against malaria: status and promise of the multi-stage malaria DNA vaccine operation. Int J Parasitol. 2001;31:753–62. doi: 10.1016/S0020-7519(01)00184-9. [DOI] [PubMed] [Google Scholar]