Abstract
Chest pain is a frequently encountered emergency room presentation, of which about 15% of cases are due to acute coronary syndromes. Cardiogenic shock is a relatively uncommon complication with associated high morbidity and mortality. Emergency medicine practitioners frequently encounter critically ill patients that require quick, definitive treatment to optimize patient outcomes. These high acuity presentations often are of relatively low occurrence which makes training residents and learners challenging.
Simulation-based medical education has been shown to enhance patient outcomes by teaching these high acuity low occurrence (HALO) presentations in a safe environment. Herein we describe a simulation scenario of a patient with cardiogenic shock secondary to acute coronary syndrome. It consists of a step-wise, detailed summary of the case, along with modifiers to adjust the case for repeated use, learning objectives, and a suggested evaluation.
Keywords: myocardial infarction, cardiogenic shock, simulation-based medical education, rural medicine, emergency medicine
Introduction
Ischemic heart disease (IHD) is the leading cause of death among adults in Canada, with more than 600,000 people dying annually [1]. Coronary artery disease (CAD) accounts for the vast majority of patients with IHD. The main symptom of CAD is chest pain, which results in over 8 million presentations to the emergency department annually [2]. Of those, approximately 15% have acute coronary syndrome (ACS), a third of whom have an acute myocardial infarction (MI) [3]. About 5-10% of patients with acute MI have cardiogenic shock, rendering it a rare but potentially lethal presentation.
Cardiogenic shock is the leading cause of in-hospital death in patients with acute MI [3] and seen in 4-8% of patients with ST-segment elevation myocardial infarction (STEMI) [4]. Depending on the area and extent of infarct, mechanical complications, including rupture of the septum, ventricular wall, or chordae tendinae, may or may not be present [5]. It occurs less frequently in patients with non-ST-segment elevation myocardial infarction (NSTEMI). About 10% of acute MI patients who will develop cardiogenic shock have it at presentation, with the median onset after arrival being approximately six hours. Cardiogenic shock is associated with a mortality of about 40%, with about half of the deaths occurring within the first 48 hours after presentation [6]. Therefore, early recognition of cardiogenic shock or ongoing myocardial ischemia is key for rural family medicine trainees. Early and effective management is key in restoring perfusion and optimizing patient outcomes.
People living in rural communities report higher levels of cardiovascular disease risk factors, including smoking, obesity, and inactivity compared to their urban counterparts. They also report higher levels of heart disease, hypertension, and stroke [7]. Due to a multitude of factors, cardiologists are less likely to establish a full-time practice in rural areas [8]. Consequently, rural patients have fewer overall visits to specialists and tend to rely heavily on care provided locally by primary care physicians. Predicting the clinical course in these critically ill patients can be quite challenging and determining whether a particular rural hospital has the capacity to care for such a patient is complex. Patients often want to remain local for treatment whenever possible, however, transport to a tertiary care centre sometimes becomes necessary [9].
Presently, teaching around this subject is largely didactic. Continuing medical education (CME) courses such as advanced cardiac life support (ACLS) offer a mix of didactic lessons and simulated cases. Simulation-based medical education has been repeatedly shown to affect learner skills, knowledge and attitudes, and patient outcomes [10]. It serves as a medium to teach high acuity low occurrence (HALO) and crisis resource management (CRM) skills and presentations in a safe environment. As such, it has become a mainstay of many postgraduate medical training programs. Recently, with the transition to the Competency by Design initiative for all Canadian postgraduate medical education programs, simulation will likely take a more predominant role in assessment.
This technical report is designed to train rural family and emergency medicine trainees in recognizing cardiogenic shock and quickly initiating the appropriate management steps. The objectives of this simulation scenario are:
1. Develop an approach to a patient with chest pain.
2. Communicate effectively with team members in the care of a complex, critically ill patient.
3. Recognize and manage evolving chest pain and cardiogenic shock.
4. Develop an approach to intubation in a patient with cardiogenic shock.
This report will be presented according to the Context-Inputs-Process-Product model [11].
Technical report
Context
This simulation scenario was designed for the training of rural family or emergency medicine residents. However, any learner, rural or urban, who attends calls as part of a hospitalist rotation, whether undergraduate or postgraduate, may benefit from participation. It was designed to take place in a community hospital with no subspecialty backup in-house.
The scenario is run with the help of a confederate, an individual who, during the course of the scenario, provides assistance with equipment, provides information about the mannequin not available in other ways (e.g. temperature, colour change), and/or to provide additional realism by playing the role of a relative or staff member [12].
Three to four residents participate in the scenario, one as a team leader and the others in additional roles. If the scenario is run with only one resident, the resident is to assume the role of team leader and available confederates (e.g. nurses, respiratory therapists, other physicians, etc.) can be used as the additional team members.
Inputs
Personnel
Two facilitators, who were familiar with the scenario and its management, were present during the scenario. One ran the scenario, took notes, and provided prompts as needed. The other acted as a nurse confederate assisting with the scenario in order to meet the learning objectives. They performed tasks for the learners as requested and delivered results and prompts to the learners when needed. When fewer residents are available to partake in the simulation, more confederates may be used to assist the learners.
Equipment
The simulation session was conducted in a simulation lab using a Laerdal SimMan 3G® human patient simulator. The lab was outfitted with equipment, medications, and supplies typically available on a crash cart as well as those needed specifically for this case. The equipment and supplies are used only for simulation and teaching but are the same as what would be used in the hospital. The simulation lab is separate from the hospital and all equipment is clearly marked. The equipment provided included the following items:
- Advanced cardiac life support defibrillator and standard medications
- Airway supplies including oxygenation, intubation supplies, and suction
- Hospital chart and electrocardiograms (EKG)
- Intravenous (IV) access supplies and fluids
- Cardiac and oxygen monitors
- Medications, including vasopressors and inotropes
Higher fidelity simulation, defined as the level of realism associated with a particular simulation activity, is typically desirable. It is normally achieved by manipulating the realism of the simulator, the environment, or the scenario itself [13]. Lower fidelity simulators can be substituted for practice and integration into the scenario.
Process One week prior to the session, a step-wise, detailed scenario template (Table 1) was generated and reviewed by the scenario facilitators. This allowed for programming of the mannequin as well as preparation of supporting materials for the scenario itself. In addition, this provided some time for the facilitators to review the scenario and complete a dry run of the scenario to identify any potential problem areas.
Table 1. Step-wise, detailed scenario template.
BIPAP – bilevel positive airway pressure; BP – blood pressure; bpm – beats per minute; CPR – cardiopulmonary resuscitation; CXR – chest radiograph; EKG – electrocardiogram; HR – heart rate; ICU – intensive care unit; IV – intravenous; min – minutes; Nitro – nitrogylcerin; NRB – non-rebreather; Q – every; RA – room air; RR – respiratory rate; RT – respiratory therapist; SL – sublingual; SOB – short of breath; SpO2 – oxygen saturation; T – temperature; VBG – venous blood gas; VT – ventricular tachycardia
STATE | STATUS | LEARNER ACTIONS | OPERATOR NOTES |
1. Nurse call | Nurse calls or presents with chart. Shows most recent EKG (Figure 1) and does not provide vitals. | Ask nurse for vitals | |
Ask nurse for previous EKG | |||
As nurse for chart | |||
Instruct nurse to place patient on monitors | |||
Go see patient | |||
2. Initial assessment | T: 36.7 °C | Get IV access | Modifiers: |
HR: 101 bpm | Apply oxygen | No repeat EKG → Nurse to cue | |
BP: 181/94 | Draw bloodwork including VBG and troponin | Patient to cue still having chest pain after each spray of nitro | |
RR: 28 | EKG | Triggers: | |
SpO2: 91% RA | Read through chart | Nitro ×3 → 3. Deterioration | |
Patient alert and able to answer questions. Diaphoretic | Nitro spray 0.4 mg SL Q5min ×3 | After 5 min nurse to cue patient looks more SOB → 3. Deterioration | |
3. Deterioration | T: 36.7 °C | Trial 250-500 mL crystalloid bolus | Modifiers: |
HR: 110 bpm | Repeat EKG, can consider 15 lead | Bolus given → BP 90/50 | |
BP: 84/40 | Capillary sugar | After 5 min, BP and SpO2 continue to trend down | |
RR: 30 | Prepare for intubation | Triggers: | |
SpO2: 85% on 100% NRB | Prepare for intubation → 4. Intubation | ||
Patient confused. Cool, clammy. | No intubation prep → nurse to cue calling RT → 4. Intubation | ||
4. Intubation | As above | Consider BiPAP | Modifiers: |
Pre-medicate with fentanyl | Propofol used or unsafe intubation → 5. VF arrest | ||
Induce with ketamine | Triggers: | ||
Paralytic used | Intubation successful → 6. Ongoing hypotension | ||
Vasopressor at bedside | |||
5. VF arrest | Patient pulseless and unresponsive. | High quality CPR | Triggers: |
Defibrillate | 2 cycles CPR → 6. Ongoing hypotension | ||
Epinephrine 1 mg IV Q3min | |||
Amiodarone 300 mg IV | |||
6. Ongoing hypotension | T: 36.7 °C | CXR (Figure 2) | Modifiers: |
HR: 120 bpm | Sedation | Norepinephrine started → BP 70/40 | |
BP: 65/30 | Heparin | Norepinephrine titrated up 2-3× → BP 80/45 | |
SpO2: 92% on 100% O2 | Start norepinephrine infusion and titrate up | Dobutamine added → BP 90/50 | |
Consider another 500 mL crystalloid bolus | Triggers: | ||
Consider starting dobutamine | Vasopressor and inotrope started → 7. Stabilization | ||
Consider consult cardiology/ICU → 7. Stabilization | |||
7. Stabilization | As above. | Finish tasks from above | END OF SCENARIO |
Consult cardiology if not done |
Pre-Briefing
A pre-briefing was held with all learners prior to the case. Learners were given a brief orientation to the simulation lab and mannequin. Limitations of simulation were reviewed, in particular addressing technical issues with the mannequin and resource availability. The fiction contract was addressed. This concept, also known as the "suspension of disbelief", encourages healthcare trainees and instructors to accept the simulation exercise as being real for the duration of the scenario in order to make it worthwhile [12]. Finally, learners were advised that the case was strictly formative.
Pre-scenario Information
You are a resident working overnight in the emergency department of your community hospital. A nurse from the inpatient ward comes to your office with an EKG from a patient who was admitted earlier in the day and is currently complaining of chest pain.
The Simulation
Table 1 depicts a step-wise, detailed scenario that was submitted to technical staff to run the simulation. Investigations that may be ordered, including EKG (Figure 1) and a chest radiograph (Figure 2) are provided upon learner request.
Figure 1. EKG showing inferior ST elevation myocardial infarction [14].
Figure adapted from the website Life in the Fast Lane (https://litfl.com/) [14].
Figure 2. Chest radiograph showing pulmonary edema.
Figure adapted from Radiopedia (radiopedia.org) [15].
Debriefing and Post-Scenario Didactics
Following the conclusion of the scenario, facilitators and learners participated in a debriefing session. The debriefing was led by an experienced educator. Care was taken to ensure that the number of instructors to learners was approximately 1:1. Multiple debriefing models have been validated and choice usually is dictated by facilitator preference [16]. In this particular scenario, a modified plus/delta model was used [12]. Confederates and any simulated patients attended the start of the debriefing session to provide and receive feedback.
The content of the debriefing session was guided by the case learning objectives, yet it was a fluid process to accommodate the evolving dynamics of the team behaviour. That is, depending on how the scenario evolves, modifications were made to address any learning needs that arise. In this session, residents were taught around what to expect clinically from each infarct territory, the importance of serial EKGs, and the management of cardiogenic shock in the context of an acute MI. Considerations, such as the use of small boluses, vasopressor initiation, and when to consult a specialty service were also covered. The use and contraindications of TNK and intubation techniques were discussed. An approach to chest pain, including a differential diagnosis of non-cardiac causes of chest pain was also discussed. Additional objectives may be included by individual facilitators depending on local goals of the session. In cases such as this where transfer may be required, there is an opportunity to discuss local protocols and considerations such as weather and resource management.
Modifiers for the case can be applied in a variety of ways to both adjust difficulty and allow repeated use of the case, highlighting different points at each encounter. Some such modifications are included in Table 2. One such modification could include death as the end scenario. Currently, there exists much discussion about the benefits of including death as an outcome in simulation-based medical education [17-18]. Depending on learner objectives, facilitators could include an unsuccessful resuscitation as an optional end to the case.
Table 2. Sample modifiers that could be incorporated in the scenario.
TNK – tenecteplase
Feature | Modifier and Comments |
Simulated patient confederates | |
Family member | Distressed, emotional, interfering |
Thrombolization | |
TNK | The decision can be made to include this or not based on local learning objectives (e.g. protocols or exclusion criteria) |
Location | |
Remote nursing clinic | Could receive the call from a remote nursing clinic, making an assessment necessary through videoconference and have to run the code via telemedicine |
Ultrasound | |
Bedside echo | Can be an additional teaching point on a standardized patient confederate |
Transport | |
Medevac | Weather down, no immediate access |
Transportation considerations | Have to assemble and prepare equipment for transport |
Simulation Outcome | |
Death as a potential endpoint | For the advanced learner. Facilitators should decide beforehand if this will be a specific outcome. |
Code discussion/Family meeting | Facilitators can decide beforehand if this will be a specific objective |
A 90-minute didactic teaching session was also included to provide further teaching on topics relating to the case objectives. The incorporation of teaching following the simulation has been shown to be superior to pre-simulation instruction alone [10]. This was broken down into 45 minutes immediately following the scenario and an additional 45 minutes in a separate teaching session the following morning.
Product
The expected learning outcomes for each participant are outlined by the learning objectives for this case:
1. Develop an approach to a patient with chest pain
2. Communicate effectively with team members in the care of a complex, critically ill patient
3. Recognize and manage evolving chest pain and cardiogenic shock
4. Develop an approach to intubation in a patient with cardiogenic shock
Although this simulation was held as a formative session, a locally developed global rating scale was used to quantitatively assess the learning objectives. It is included in Table 3.
Table 3. Locally-developed global rating scale.
ACS - acute coronary syndrome
Clearly below expectations | Acceptable performance | Performs above expectations | |||
Initial management of a patient with chest pain | 1 | 2 | 3 | 4 | 5 |
Demonstrates deficient knowledge of acute cardiac presentations without recognizing and correcting it. | Weak knowledge of acute cardiac presentations. Made errors but did not recognize or correct them. | Competent performance that indicates working knowledge of ACS but committed some minor errors that were recognized and corrected. | Competent performance that indicates working knowledge of ACS but committed a minor error or did not recognize and initiate treatment in a timely manner. | Quickly recognizes and initiates appropriate management of ACS. | |
Communication | 1 | 2 | 3 | 4 | 5 |
Does not communicate well with team. Does not acknowledge team communication. Does not use directed verbal/non-verbal communication. | Weak communication with team. Vague and unclear team communication. Weak directed verbal/non-verbal communication. | Communicates mostly with team, but unclear and vague at times. Usually uses directed verbal/non-verbal communication. | Usually communicates with team, but occasionally is vague or unclear. Usually uses closed-loop communication. Usually uses directed verbal/non-verbal communication. | Exemplary closed-loop communication with team. Consistently uses directed verbal/non-verbal communication. | |
Management of cardiogenic shock | 1 | 2 | 3 | 4 | 5 |
Demonstrates deficient knowledge of cardiogenic shock without recognizing and correcting it. | Weak knowledge of cardiogenic shock. Made errors without recognizing or correcting them. | Competent performance that indicates working knowledge of cardiogenic shock but committed some minor errors that were recognized and corrected. | Competent performance that indicates working knowledge of cardiogenic shock but management could be improved. | Quickly recognizes and initiates appropriate management of cardiogenic shock. | |
Intubation: Organization and selection of supplies | 1 | 2 | 3 | 4 | 5 |
Fails to select correct materials and/or instruments for task. Does not organize appropriately prior to starting task. Does not take into account back up ventilation. | Selects some appropriate materials but forgets others. Unorganized approach. Minimal backup plan. | Slowly selects appropriate materials. Organizes them but not in a manner that helps improve efficiency with performing task or has some materials but not organized before performance of the task begins. | Selects correct materials and instruments for task. Mostly organized. Back-up plan considered. Could improve on time or organization but competent. | Quickly and confidently selects correct materials and instruments for task. Organizes in a deliberate manner that facilitates task. Materials are ready before performance of task begins. Has a back-up ventilation plan ready. | |
Intubation: Correct use of instruments | 1 | 2 | 3 | 4 | 5 |
Student may use an instrument incorrectly and does not correct mistake. | Student may use an instrument incorrectly and may correct mistake or vocalize the error. | Student uses instrument correctly for most part. Occasional errors are made but awareness and correction is demonstrated. | Student holds and uses instruments correctly. Technique mostly smooth, could use some minor suggestions. No errors in use or handling occur. | Student holds and uses instruments correctly throughout using proficient and smooth technique. No errors in use or handling occur. |
Following the scenario, an anonymous survey is circulated to all participants. This allows the facilitators to gather feedback from the participants over the next few days following the session. Examples of questions circulated are included in Table 4.
Table 4. Post-scenario survey questions.
Post-Scenario Survey Questions |
Level of training |
What did you like today? |
What worked well? |
What didn't work as well? |
Did you find the simulation realistic? |
Suggestions for future simulations/skill sessions? |
Discussion
In over 70% of cases, cardiogenic shock is related to acute myocardial infarction with ST-segment elevation. The management of acute MI with or without cardiogenic shock is crucial for anyone practicing acute care medicine - both in rural and urban centres.
For example, medical trainees across multiple disciplines often have to complete off-service rotations in which on-call coverage of a medical floor is necessary. Therefore, the quick recognition and management of acute coronary syndrome, including acute myocardial infarction and cardiogenic shock is imperative.
Physicians practicing in rural locations tend to have broad scopes of practice and as such are responsible for managing such presentations until transfer to a tertiary care centre can be arranged [19-20]. Local considerations, such as weather, mode of transport, and resource availability become important and are easily included in the scenario.
This scenario was initially run in small groups (three to four learners per session) of rural family medicine residents and medical students. Scenario subject and learning objectives were not distributed prior to the session. Learners were encouraged to use any available resources - including books, ACLS algorithms, and web applications - during an emergency department or call shift. The didactic session focused largely on the aforementioned learning objectives, and a written handout was circulated to learners following the session. A second teaching session, within the subsequent two weeks, was held to incorporate some Point of Care Ultrasound (PoCUS) teaching around echocardiography. Feedback on the scenario was largely positive, in particular surrounding the management of cardiogenic shock. There were suggestions around in situ simulation of this case rendering it more realistic, but unfortunately, that was not possible at the time of the sessions. Instead, future sessions will incorporate some other allied health care professionals (including nursing and respiratory therapy) to work on team functioning along with the scenario.
Future work includes validation of the locally developed GRS as the simulation is repeated over time with different learners. This would allow for the provision of objective feedback to the learner in a structured approach. As well, this scenario is a part of a larger curriculum developed for rural and remote trainees and will evolve as required to reflect local learning objectives.
The development of this scenario in a step-wise fashion allows the simulation to react according to learner actions. The list of modifiers included in Table 2 allows for an easily adaptable scenario that can be repeated according to local learning objectives. Having a facilitator review the scenario in advance ensures that it is of reasonable difficulty for the intended learner group and allows instructors to identify any shortcomings of the scenario. Finally, the coupling of a formal debriefing with a didactic learning session allows for both the collaborative identification of knowledge gaps and process errors that may arise during the scenario.
Conclusions
The use of simulation in teaching rural medicine trainees to manage acute myocardial infarction and cardiogenic shock may close a learning gap. These situations can be very demanding and emotionally charged. Therefore, practice in a controlled environment can be beneficial for rural family medicine trainees, ultimately improving both learner comfort and patient outcomes. We have presented herein an acute STEMI with cardiogenic shock, along with scenario modifiers, and post-scenario didactics and teaching, designed for rural family medicine trainees.
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research and reference purposes. Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus.
The authors have declared that no competing interests exist.
Human Ethics
Consent was obtained by all participants in this study
Animal Ethics
Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue.
References
- 1.Heart disease and stroke statistics—2019 update: a report from the American Heart Association. Benjamin EJ, Muntner P, Alonso A, et al. Circulation. 2019;139:0–528. doi: 10.1161/CIR.0000000000000659. [DOI] [PubMed] [Google Scholar]
- 2.NCHS Data Brief. Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999-2010. [May;2019 ];Fryar CD, Chen T-C, Li X. https://www.cdc.gov/nchs/data/databriefs/db103.pdf. NCHS data brief. 2012 103 [PubMed] [Google Scholar]
- 3.Hollander JE, Diercks DB. Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8th ed. New York: McGraw Hill Education; 2016. Acute coronary syndromes; pp. 332–352. [Google Scholar]
- 4.Improved outcome of cardiogenic shock at the acute stage of myocardial infarction: a report from the USIK 1995, USIC 2000, and FAST-MI French Nationwide Registries. Aissaoui N, Puymirat E, Tabone X, et al. Eur Heart J. 2012;33:2535–2543. doi: 10.1093/eurheartj/ehs264. [DOI] [PubMed] [Google Scholar]
- 5.Experts’ recommendations for the management of adult patients with cardiogenic shock. Levy B, Bastien O, Karim B, et al. Ann Intensive Care. 2015;5:52. doi: 10.1186/s13613-015-0052-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.PCI strategies in patients with acute myocardial infarction and cardiogenic shock. Thiele H, Akin I, Sandri M, et al. N Engl J Med. 2017;21:2419–2432. doi: 10.1056/NEJMoa1710261. [DOI] [PubMed] [Google Scholar]
- 7.Providing cardiology care in rural areas through visiting consultant clinics. Gruca TS, Pyo TR, Nelson GC. J Am Heart Assoc. 2018;5:2909. doi: 10.1161/JAHA.115.002909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.The shortage of on-call surgical specialist coverage: a national survey of emergency department directors. Rao MB, Lerro C, Gross CP. Acad Emerg Med. 2010;17:1374–1382. doi: 10.1111/j.1553-2712.2010.00927.x. [DOI] [PubMed] [Google Scholar]
- 9.Discordance between patient and clinician experiences and priorities in rural interhospital transfer: a mixed methods study. Mohr NM, Wong TS, Faine B, et al. J Rural Health. 2016;32:25–34. doi: 10.1111/jrh.12125. [DOI] [PubMed] [Google Scholar]
- 10.Simulation in healthcare education: A best evidence practical guide. AMEE Guide No 82. Motola I, Devine LA, Chung HS, et al. Med Teach. 2013;10:0–30. doi: 10.3109/0142159X.2013.818632. [DOI] [PubMed] [Google Scholar]
- 11.Evaluation checklists: practical tools for guiding and judging evaluations. Stufflebeam DL. Am J Eval. 2001;22:71–79. [Google Scholar]
- 12.Lioce L, Lopreiato J, Downing D, et al. Vol. 16. Rockville, MD: Agency for Healthcare Research and Quality; 2020. Healthcare Simulation Dictionary, 2nd ed; p. 43. [Google Scholar]
- 13.INACSL standards of best practice: Simulation Simulation design. INACSL Standards Committee. Clin Simul Nurs. 2016;12:0–12. [Google Scholar]
- 14.Life in the Fast Lane. Inferior STEMI. [May;2019 ];https://litfl.com/inferior-stemi-ecg-library/ 2019
- 15.Radiopedia. Acute pulmonary edema. [Jun;2020 ];https://radiopaedia.org/cases/apo-arrowsjpg 2017
- 16.Introduction to debriefing. Gardner R. Sem Perinatol. 2013;37:166–174. doi: 10.1053/j.semperi.2013.02.008. [DOI] [PubMed] [Google Scholar]
- 17.To die or not to die? A review of simulated death. Corvetto MA, Taekman JM. Simul Healthc. 2013;8:8–12. doi: 10.1097/SIH.0b013e3182689aff. [DOI] [PubMed] [Google Scholar]
- 18.Simulated death enhances learner attitudes regarding simulation. Park CH, Wetmore D, Katz D, DeMaria S, Levine AI, Goldberg AT. BMJ Simul Technol Enhanc Learn. 2018;4:23–26. doi: 10.1136/bmjstel-2017-000215. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Does geography matter in mortality? An analysis of potentially avoidable mortality by remoteness index in Canada. Subedi R, Greenberg TL, Roshanafshar S. Health Rep. 2019;30:3–15. doi: 10.25318/82-003-x201900500001-eng. [DOI] [PubMed] [Google Scholar]
- 20.Development of a rural health framework: Implications for program service planning and delivery. White D. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999556/ Healthc Policy. 2013;8:27–41. [PMC free article] [PubMed] [Google Scholar]