Table 4.
Papp of ibuprofen in the ileum and the enhancement ratio of the emulsion formulations when compared with control. Results are expressed as the mean ± S.E of at least 3 experiments. ∗P < 0.01, ∗P < 0.05, N.S. no significance different, compared with the control.
| Formulation | Ibuprofen concentration (w/w) | Papp (x10−6 cm/s) | Enhancement ratio |
|---|---|---|---|
| Control | 3.0% | 1.3 ± 0.2 | - |
| Ibuprofen nanoemulsion (NE) | 1.5% | 8.1 ± 1.9∗∗ | 6.2 |
| 3.0% | 13.8 ± 2.2∗∗ | 10.6 | |
| 6.0% | 8.6 ± 0.5∗∗ | 6.6 | |
| Ibuprofen microemulsion A (ME A) |
1.5% | 3.9 ± 0.2∗∗ | 3.0 |
| 3.0% | 6.9 ± 2.5∗∗ | 5.3 | |
| 6.0% | 5.4 ± 0.6∗∗ | 4.2 | |
| Ibuprofen microemulsion B (ME B) |
1.5% | 1.4 ± 0.1N.S. | 1.1 |
| 3.0% | 1.8 ± 0.2N.S. | 1.4 | |
| 6.0% | 1.6 ± 0.1N.S. | 1.2 |