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Safety-by-Design approach. Blue arrows correspond to the flow of polymeric nanobiomaterials as drug delivery systems from design to storage and transport, red arrows are feedback loops uses whenever the nanobiomaterial product is unsafe, inefficient or has unwanted side effects, and bullet points represent the methods/tools or endpoints at each step. Reprinted from [228]. Copyright (2020) Schmutz, Borges, Jesus, Borchard, Perale, Zinn, Sips, Soeteman-Hernandez, Wick and Som.
