Scheme 1.
The synthetic route of 4a–4u. Reagents and conditions: (a) glycolic acid, 4N HCl, 100 °C, 6 h; (b) benzyl bromides, K2CO3, DMF, rt, 24 h; (c) Dess-Martin periodinane, DCM, 0 °C, 1 h; (d) ArCOCH3, EtOH, 10% NaOH, rt, 1 h.
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