Erratum. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK

Hum Reprod 2020;35:1145–1158

Oxford University Press would like to apologise for a typesetting error in Figure 5 of the above article. A repeat of Figure 4 was published instead of Figure 5. The correct figure is reproduced below.

The electronic version of this article has been updated at https://doi.org/10.1093/humrep/deaa077.

Figure 5.

Ameliorative effects of metformin on testosterone-induced endoplasmic reticulum (ER) stress in cumulus oocyte complexes (COCs) mediated via reduction of p38 MAPK phosphorylation. (A) Unfolded protein response (UPR) sensor protein levels in COCs treated with 10 μM testosterone (T) and 1 mM metformin (met). (B) Changes in ER stress-related protein levels in COCs treated with 10 μM testosterone and 10 μM SB203580 (a p38 MAPK inhibitor) as detected by western blot. (C) Western blot results showing the changes in the indicated proteins in COCs treated with 10 μM testosterone after transfection with si-p38 MAPK. Real-time qPCR results showing the effects of SB203580 (D) and si-p38 MAPK (E) on ER stress-related mRNA transcription levels in COCs treated with 10 μM testosterone; the signals were normalized to those of Gapdh. The data are presented as means ± SEMs. ^*P < 0.05, ^**P < 0.01. Si-nc, negative control siRNA; Met, metformin; T, testosterone.