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Conversion to sinus rhythm over time after start of drug therapy for recent-onset AF. Class Ic AADs foreshorten time to sinus rhythm significantly. Amiodarone and non-AAD (rate control drugs) are associated with spontaneous conversion, with minimal conversion action of amiodarone discernable from 6 h on. At the end of the day around 60–70% of patients reached sinus rhythm. Modified after Crijns et al.,10 with permission. AAD, antiarrhythmic drug; AF, atrial fibrillation.
