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. 2020 Aug 3;157:33. doi: 10.1186/s41065-020-00146-w

Table 1.

Basic information of the association between 4 SNPs in MBL2 and TB, especially for PTB susceptibility

First author Year Origin Ethnicity Source of Type Case Control Case Control Method NOS
Ref No Control MM MW WW MM MW WW
rs7096206 XX/GG XY/GC YY/CC XX/GG XY/GC YY/CC HWE
Liu [10] 2006 China Asian PB PTB 141 212 6 44 91 7 54 151 0.43 PCR-SSP/PCR-SSOP 7
Wu 2017 China Asian HB PTB 151 453 7 47 97 15 120 318 0.379 PCR-RFLP/PCR-SSCP 6
Thye [41] 2011 Germany Caucasian PB PTB 1859 2180 26 396 1437 31 486 1663 0.503 DASH-FRET 7
Feng [30] 2016 China Asian HB PTB 99 89 0 9 90 1 26 62 0.336 Taqman 5
Liu 2015 China Asian HB PTB 112 120 11 35 66 2 40 78 0.215 PCR-RFLP 7
Chen [24] 2014 China Asian PB PTB 205 216 5 77 123 8 49 159 0.098 PCR-SSP 7
Wang [42] 2009 China Asian PB PTB 449 249 12 122 315 7 61 181 0.503 AMLR 7
Alagarasu [19] 2007 India Asian HB total 109 146 3 44 62 13 61 72 0.987 PCR-SSP 6
Chen [25] 2015 China Asian PB total 503 419 12 166 325 10 113 296 0.839 PCR-SSP 8
Amiri [20] 2017 Iran Asian PB PTB 100 100 5 36 59 7 29 64 0.159 PCR-SSP 7
Cruz [27] 2013 Brazil Caucasian HB PTB 119 148 4 40 75 6 32 110 0.076 Sequencing 6
Cruz [27] 2013 Brazil Caucasian HB EPTB 36 148 1 9 26 6 32 110 0.076 Sequencing 6
rs11003125 LL LH HH LL LH HH HWE
Liu [10] 2006 China Asian PB PTB 141 212 31 66 44 58 105 49 0.911 PCR-SSP/PCR-SSOP 7
Thye [41] 2011 Germany Caucasian PB PTB 1843 2174 7 265 1571 9 287 1878 0.577 DASH-FRET 7
Feng [30] 2016 China Asian HB PTB 99 89 28 45 26 21 36 32 0.092 Taqman 5
Li [34] 2011 China Asian PB PTB 231 226 34 92 105 31 106 89 0.949 PCR-SSP 7
Wu 2017 China Asian HB PTB 151 453 41 64 46 104 248 101 0.043 PCR-RFLP/PCR-SSCP 6
Zhou [46] 2011 China Asian HB PTB 226 141 58 101 67 42 10 89 < 0.01 PCR-SSP 6
Zhang [44] 2011 China Asian HB PTB 220 213 29 75 116 51 76 86 < 0.01 PCR-SSP 6
Wang [42] 2009 China Asian PB PTB 449 249 91 235 123 60 108 81 0.046 AMLR 7
Amiri [20] 2017 Iran Asian PB PTB 100 100 22 43 35 30 48 22 0.735 PCR-SSP 7
Cruz [27] 2013 Brazil Caucasian HB PTB 119 148 66 45 8 68 61 19 0.367 Sequencing 6
Cruz [27] 2013 Brazil Caucasian HB EPTB 36 148 16 18 2 68 61 19 0.367 Sequencing 6
rs7095891 QQ QP PP QQ QP PP HWE
Liu [10] 2006 China Asian PB PTB 141 212 1 22 118 2 39 171 0.891 PCR-SSP/PCR-SSOP 7
Wu 2017 China Asian HB PTB 151 453 1 26 124 2 87 364 0.181 PCR-RFLP/PCR-SSCP 6
Thye [41] 2011 Germany Caucasian PB PTB 1953 2230 308 920 725 319 1086 825 0.205 DASH-FRET 7
Zhou [46] 2011 China Asian HB PTB 226 231 24 90 112 25 89 117 0.201 PCR-SSP 6
Feng [30] 2016 China Asian HB PTB 99 89 7 34 58 0 24 65 0.141 Taqman 5
Wang [42] 2009 China Asian PB PTB 449 249 3 114 332 2 64 183 0.155 AMLR 7
Zhang [44] 2011 China Asian HB PTB 220 213 17 31 172 21 36 156 < 0.01 PCR-SSP 6
Amiri [20] 2017 Iran Asian PB PTB 100 100 3 21 76 5 26 69 0.233 PCR-SSP 7
AA/AO/OO OO OA AA OO OA AA HWE
Garcia-Laorden [17] 2006 Spain Caucasian HB total 106 344 3 33 70 27 134 183 0.721 PCR-RFLP 6
Søborg 2003 Denmark Caucasian PB

total/

White

 59 250 4 18 37 7 86 157 0.235 PCR-SSP 8
Søborg 2003 Denmark Caucasian PB

total/

Nonwhite

 50 250 4 12 34 7 86 157 0.235 PCR-SSP 8
Capparelli [22] 2009 Italy Caucasian HB PTB 274 288 61 158 55 10 112 166 0.087 Sequencing 6
Garcıa-Gasalla [32] 2014 Spain Caucasian HB total 76 106 4 24 48 1 34 71 0.156 PCR-SSP 6
Alagarasu [19] 2007 India Asian HB total 275 146 25 87 145 7 53 86 0.747 PCR-SSP 6
Zhao [45] 2014 China Asian PB PTB 900 870 101 279 520 53 303 514 0.352 PCR-RFLP 7
Li [34] 2011 China Asian PB PTB 231 226 3 57 171 3 37 186 0.461 PCR-SSP 7
Li [33] 2009 China Asian HB PTB 141 152 6 56 79 8 38 106 0.075 PCR-SSP 6
Liu [10] 2006 China Asian PB PTB 141 212 4 34 103 4 42 166 0.487 PCR-SSP/PCR-SSOP 7
Zhou [47] 2012 China Asian HB PTB 226 231 14 106 106 5 80 146 0.114 PCR-SSP 6
Liu 2015 China Asian HB PTB 112 120 3 29 80 2 22 96 0.576 PCR-RFLP 7
Fang [29] 2011 China Asian HB PTB 100 100 1 25 74 0 25 75 0.153 PCR-RFLP 6
Wu 2017 China Asian HB PTB 151 454 2 37 112 8 97 348 0.681 PCR-RFLP/PCR-SSCP 6
Singla 2011 India Asian HB PTB 286 397 11 100 175 35 155 207 0.441 PCR-RFLP 6
Singla 2011 India Asian HB EPTB 71 397 2 26 43 35 155 207 0.441 PCR-RFLP 6
Özbaþ-Gerçeker 2003 Turkey Caucasian PB PTB 49 100 0 9 40 4 20 76 0.09 PCR 7
Wit [28] 2011 South Africa African PB total 499 313 2 134 363 0 102 211 < 0.01 PCR-RFLP 8
Feng [30] 2016 China Asian HB PTB 381 267 14 177 190 12 176 79 < 0.01 Taqman 5
Wang [42] 2009 China Asian PB PTB 449 249 4 133 312 3 82 164 0.038 AMLR 7
Thye [41] 2011 Germany Caucasian PB PTB 1893 1040 193 815 885 126 426 488 0.029 DASH-FRET 7
Ceylan [23] 2017 Turkey Caucasian HB total 69 70 8 13 48 12 11 47 < 0.01 PCR-RFLP 7
Amiri [20] 2017 Iran Asian PB PTB 100 100 2 29 69 1 27 72 0.374 PCR-SSP 7
Cruz [27] 2013 Brazil Caucasian HB PTB 119 148 7 41 71 6 34 108 0.129 Sequencing 6
Cruz [27] 2013 Brazil Caucasian HB EPTB 36 148 1 14 21 6 34 108 0.129 Sequencing 6
Selvaraj [37] 1999 India Asian PB PTB 202 109 22 73 107 2 39 68 0.175 PCR-RFLP 7
Araújo 2013 Brazil Caucasian HB PTB 133 159 2 47 84 2 56 101 0.058 PCR 6
Araújo 2013 Brazil Caucasian HB EPTB 34 159 1 15 18 2 56 101 0.058 PCR 6
Fitness [31] 2004 UK Caucasian PB total 322 546 12 105 205 24 160 362 0.245 fluorescence PCR/ARMS-PCR 7
Søborg 2007 Denmark Caucasian PB PTB 443 432 22 132 289 30 131 271 0.013 PCR-RFLP/PCR-SSP 7

HWE Hardy-Weinberg equilibrium; M Mutated allele; W Wide type allele; HB Hospital-based; PB Population-based; TB Tuberculosis; PTB: Pulmonary TB, EPTB Extra-pulmonary TB; PCR-FLIP Polymerase chain reaction and restrictive fragment length polymorphism; SSP Sequence specific primer; SSOP Sequence-specific oligonucleotide probe; SSCP Single-strand conformation polymorphism; DASH-FRET Dynamic allele-specific hybridization with fluorescence resonance energy transfer; AMLR Allelic-specific multiplex ligase-detection reaction; ARMS Amplification refractory mutation system; NOS Newcastle-Ottawa scale