Table 5.

Hazard ratios (HR) and 95% confidence intervals (CI) for cancer mortality by inflammatory and metabolic biomarkers by race

	BMI categories
	Normal BMI (18.5 ≤ BMI <25 kg/m²)	Ove rweight or Obese (BMI ≥25 kg/m²)	p_{int with BMI}
	Log-Transformed^§	*Log Transformed*^§
Black Participants (N=798, cancer death=40)
IL-6
Model 1	3.6(1.2, 10.6)^*	3.4 (1.6, 7.0)^**	0.008
Model 2	4.7 (1.3, 16.9)^*	3.3 (1.6, 7.0)^*	0.021
Model 3	5.9 (1.5, 23.1)^*	3.0 (1.3, 6.9)^*	0.156
CRP
Model 1	1.4 (0.9, 2.0)	1.3 (0.9, 2.0)	0.039
Model 2	1.4 (0.9, 1.9)	1.3 (0.9, 2.0)	0.043
Model 3	1.3 (0.7, 2.2)	1.3 (0.9, 2.0)	0.396
Resistin
Model 1	4.4 (0.6, 31.4)	1.3 (0.7, 2.3)	0.007
Model 2	4.2 (0.7, 26.9)	1.3 (0.7, 2.3)	0.013
Model 3	8.5 (2.0, 35.8)^**	1.3 (0.7, 2.5)	0.008
White Participants (N=1024, cancer death=46)
IL-6
Model 1	2.6 (0.8, 9.1)	2.4 (1.0, 5.7)^*	0.269
Model 2	3.0 (0.8, 12.0)	3.1 (1.3, 7.5)^*	0.278
Model 3	1.0 (0.20, 4.6)	2.7 (1.1, 6.4)^*	0.649
CRP
Model 1	1.8(1.1, 3.1)^*	0.9 (0.6, 1.3)	0.115
Model 2	1.9 (1.0, 3.4)^*	0.9 (0.6, 1.4)	0.131
Model 3	1.7 (1.2, 2.5)^**	1.0 (0.6, 1.5)	0.571
Resistin
Model 1	1.3 (0.3, 5.5)	0.4 (0.1, 1.6)	0.625
Model 2	1.3 (0.3, 6.0)	0.4 (0.1, 1.8)	0.454
Model 3	3.6 (0.5, 24.2)	0.4 (0.1, 2.5)	<0.0001

Crude model included the exposure and age.

Model 1 adjusted for age, gender, education, and income

Model 2 additionally adjusted for exercise

Model 3 further adjusted for comorbidity scores, smoking, alcohol, aspirin, and statin use

^§

Biomarkers (except CRP) were log-transformed due to non-normal distributions

Bold indicates significance at 0.05 alpha level.

^**

p-values were ≤0.01;

p-values were ≤0.05 while the rest of p-values were >0.05.

pint, p for the interaction of the log form with BMI. The p-values are from type 3 tests.P for the interaction is considered significant at alpha=0.1