TABLE 6.
Primary and secondary immune variables used in conditional logistic regression models to assess associations with postnatal HIV-1 transmission
| Variable type | Immune response | Assay |
|---|---|---|
| Primary immune variables | Breast milk total IgA against HIV-1 B.con env03 gp140, measured by AUC | ELISA |
| Breast milk sIgA against HIV-1 B.con env03 gp140, measured by AUC | ELISA | |
| Breast milk ADCC antibody titer (above and below detection) | ADCC-Luc | |
| Secondary immune variables | Plasma total IgA against HIV-1 B.con env03 gp140, measured by AUC | ELISA |
| Plasma ADCC antibody titer (above and below detection) | ADCC-Luc | |
| Breast milk ADCC potency (maximum % specific killing) | ADCC-Luc | |
| Plasma ADCC potency (maximum % specific killing) | ADCC-Luc | |
| Plasma Env-specific IgG (against a panel of HIV-1 antigens) | BAMA | |
| Breast milk Env-specific IgG (against a panel of HIV-1 antigens) | BAMA | |
| Breast milk total IgA (against a panel of HIV-1 antigens) | BAMA | |
| Plasma total IgA (against a panel of HIV-1 antigens) | BAMA | |
| Breast milk sIgA (against a panel of HIV-1 antigens) | BAMA |